PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters

Proceedings of the National Academy of Sciences of the United States of America
Jennifer M GerlachPeter Gallant

Abstract

The Myc oncogene is a transcription factor with a powerful grip on cellular growth and proliferation. The physical interaction of Myc with the E-box DNA motif has been extensively characterized, but it is less clear whether this sequence-specific interaction is sufficient for Myc's binding to its transcriptional targets. Here we identify the PAF1 complex, and specifically its component Leo1, as a factor that helps recruit Myc to target genes. Since the PAF1 complex is typically associated with active genes, this interaction with Leo1 contributes to Myc targeting to open promoters.

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Citations

Nov 27, 2019·Proceedings of the National Academy of Sciences of the United States of America·Lance R ThomasWilliam P Tansey
Feb 20, 2020·Nature Reviews. Molecular Cell Biology·Apoorva BaluapuriMartin Eilers
Oct 2, 2019·Molecular and Cellular Biology·Zhuojuan LuoChengqi Lin
Feb 19, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Tianli ChenZongli Zhang

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