PAFAH1B2 is a HIF1a target gene and promotes metastasis in pancreatic cancer

Biochemical and Biophysical Research Communications
Can MaBinghui Li

Abstract

Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B2) plays important roles in inflammation and anaphylaxis. However, its primary function in pancreatic cancer remains unclear. In the current study, we report that PAFAH1B2 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) and correlated inversely with patient survival. PAFAH1B2 overexpression induced epithelial-mesenchymal transition (EMT), migration and invasion in vitro and metastasis in vivo. Conversely, silencing PAFAH1B2 inhibited these aggressive phenotypes. Moreover, PAFAH1B2 overexpression in PDAC cells was directly mediated by HIF1a. PAFAH1B2 expression in PDAC clinical specimens correlated positively with HIF1a expression. Overall, our results defined PAFAH1B2 as a target gene of HIF1a and a critical driver of PDAC metastatic behaviors.

Citations

Aug 5, 2020·Journal of Cellular Physiology·Zhirui ZengJianxin Jiang
Apr 24, 2020·Frontiers in Oncology·Shing Yau TamHelen K W Law
Feb 4, 2021·British Journal of Cancer·Romika KumariCaroline A Heckman
Oct 28, 2020·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Zhe-Yuan XuHao Peng

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