Pagetoid dyskeratosis in dermatopathology

The American Journal of Dermatopathology
Angel Santos-BrizEmilia Fernandez

Abstract

Pagetoid dyskeratosis (PD) is an incidental pathologic finding that appears in several skin conditions. In an attempt to better understand PD and its incidence in dermatopathology, the authors have analyzed all skin biopsies performed over the period of 1 year in our Department of Dermatology and examined their clinical and dermatopathological variables. The criteria used for a keratinocyte to be considered a PD cell were: (1) a size larger than normal, (2) the presence of pycnotic nucleus, (3) a clear halo surrounding the nucleus, and (4) a pale eosinophilic cytoplasm. A total of 3565 biopsies were analyzed, PD cells being found in 80 cases (2.24%). Melanocytic nevi were the commonest skin lesions in which PD was observed, followed by soft fibromas, angiofibromas, and acrochordons. Most lesions were located on the head, neck, and trunk. Most cases displayed fewer than 15 PD cells per field. PD cells were normally located in the mid epidermis (frequently in clusters). The biopsies usually revealed indirect signs of rubbing, although PD cells were also found in places where rubbing was unlikely. Here, the authors report the largest series of PD analyzed to date, expanding our understanding of this striking pathological observation.

References

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Jun 1, 1984·Journal of Cutaneous Pathology·J Civatte
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Feb 28, 2004·Journal of the American Academy of Dermatology·Linda C WangShail Busbey
Nov 24, 2006·The American Journal of Dermatopathology·Enric Piqué-DuranMa Sol Martínez-Martín
Mar 7, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M Francisca GarijoJ Fernando Val-Bernal
Nov 19, 2009·European Journal of Dermatology : EJD·Jean Kanitakis, Viviana Lora
Aug 31, 2010·The American Journal of Dermatopathology·José Fernando Val-BernalMaría Francisca Garijo

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Citations

Jun 5, 2021·Anais Brasileiros De Dermatologia·Tauana Ogata Coelho da RochaRute Facchini Lellis
Aug 20, 2021·The American Journal of Dermatopathology·Pedro ZaballosLuis Requena
Oct 6, 2021·The American Journal of Dermatopathology·Valentina CaputoFranco Rongioletti

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