Pagetoid melanocytosis: when is it significant?

Pathology
Vesna Petronic-RosicThomas Krausz

Abstract

Pagetoid melanocytosis refers to the presence of solitary and small groups of melanocytes in the superficial layers of the epidermis. Although it is generally considered to be a diagnostic hallmark of melanoma, it may also be seen in certain melanocytic naevi. Attempts to formulate reliable histological criteria for distinction between benign and malignant pagetoid melanocytosis have been only partly successful. Extensive and diffuse pagetoid spread of melanocytes, especially when it extends laterally beyond the underlying junctional component, combined with marked cytological atypia, favours melanoma (Fig. 1). In naevi, pagetoid spread tends to be more limited and there is no marked cytological atypia. Since these criteria are applicable in only a subset of cases, the correct diagnosis of melanocytic lesions must be based not only on the features of pagetoid melanocytosis but also on all histological and clinical findings. The pathogenesis of pagetoid melanocytosis is, at best, hypothetical and presumes an active infiltrative process in the setting of malignancy. However, novel data support the contention of a passive drift of melanocytes carried upwards by proliferating keratinocytes under particular circumstances, such as tr...Continue Reading

References

Nov 1, 1991·The Journal of Investigative Dermatology·G A Scott, A R Haake
Apr 1, 1989·The Journal of Investigative Dermatology·P R GordonB A Gilchrest
Apr 1, 1987·Journal of Cutaneous Pathology·W N ChristensenA F Hood
Jan 1, 1995·Archives of Dermatological Research·M TronnierH H Wolff
Feb 1, 1995·The American Journal of Dermatopathology·M Tronnier, H H Wolff
Apr 1, 1995·The Journal of Investigative Dermatology·M TronnierH H Wolff
Jul 1, 1995·The American Journal of Surgical Pathology·H M Haupt, J B Stern
Nov 1, 1994·Journal of the American Academy of Dermatology·A S Boyd, R P Rapini
Oct 1, 1993·The Journal of Investigative Dermatology·J G MorelliD A Norris
Dec 1, 1995·The American Journal of Dermatopathology·R BergmanC Lichtig
Dec 1, 1995·The American Journal of Dermatopathology·R BergmanC Lichtig
Nov 15, 1995·Cancer·R L BarnhillA Perez-Atayde
Dec 1, 1995·Histopathology·C ClementeF Rilke
Oct 10, 1998·International Journal of Cancer. Journal International Du Cancer·J M Elwood, R P Gallagher
Mar 17, 1999·The American Journal of Surgical Pathology·S SignorettiT Faraggiana
Apr 28, 1999·The American Journal of Dermatopathology·T NagasakaM Saddik
Dec 14, 1999·The Journal of Investigative Dermatology·B C BastianP E Leboit
Dec 23, 1999·The American Journal of Dermatopathology·J D Harvell, W L White
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Z KaleemM R Wick
Jun 10, 2000·Journal of Cutaneous Pathology·F RongiolettiR L Barnhill
Aug 22, 2000·The Journal of Investigative Dermatology·U B HofmannD J Ruiter
Sep 12, 2000·The American Journal of Pathology·B C BastianD Pinkel
Sep 21, 2000·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M TronnierH H Wolff
Feb 24, 2001·The American Journal of Dermatopathology·P E LeBoit
Aug 9, 2001·Journal of Cutaneous Pathology·M P HoangC R Shea
Jan 22, 2002·The American Journal of Dermatopathology·P E LeBoit
Mar 21, 2002·Pathology·Kerry A CrottyStanley W McCarthy
Mar 22, 2002·The Lancet Oncology·Dirk RuiterMeenhard Herlyn
Apr 30, 2002·The American Journal of Dermatopathology·Carmelo Urso
Jun 20, 2002·Advances in Anatomic Pathology·Wolter J Mooi
Oct 3, 2002·The American Journal of Dermatopathology·Stewart F Cramer
May 31, 2003·The American Journal of Dermatopathology·Joan M Mones, A Bernard Ackerman
Dec 18, 2003·Journal of the National Cancer Institute·Janet L MaldonadoBoris C Bastian
Dec 24, 2003·Journal of Cutaneous Pathology·F RongiolettiA Rebora

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Citations

Jan 25, 2006·Melanoma Research·Suzannah M BeroMary S Brady
Apr 17, 2014·The American Journal of Dermatopathology·Hassan HuwaitRichard I Crawford
Jun 28, 2011·The British Journal of Oral & Maxillofacial Surgery·Bara Abdul-Salam, Ahmed Messahel
Sep 13, 2008·The Journal of Investigative Dermatology·James M Grichnik
Mar 30, 2007·International Journal of Oral and Maxillofacial Surgery·J SeehraP Sloan
Mar 5, 2014·Experimental Dermatology·James M GrichnikKonstantinos E Hatzistergos
Nov 21, 2007·Virchows Archiv : an International Journal of Pathology·Aikaterini Zioga, Anna Batistatou
Jul 31, 2018·Archives of Pathology & Laboratory Medicine·Nathan T Harvey, Benjamin A Wood
Jul 12, 2019·Journal of Cutaneous Pathology·Angel Fernandez-Flores, Queila Rodríguez Jato
Aug 24, 2020·Journal of Cutaneous Pathology·Jina ChungJason B Lee

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