Pagetoid reticulosis tumor cells with double expression of TCRγδ and TCRαβ: an off-target phenomenon or genuine expression?

Journal of Cutaneous Pathology
Dario TomasiniFilippo Crivelli

Abstract

Pagetoid reticulosis (PR) is a low-grade primary cutaneous T-cell lymphoma showing localized patches or plaques with an intrapeidermal proliferation of neoplastic T-cells with heterogeneous immunophenotype. We describe a 73-year-old woman with a 8-year history of gluteal lesions of PR, whom large blast cells were CD4/CD8 double negative T-cells with an activated cytotoxic profile. The case was investigated using a broad panel of monoclonal antibodies including TCRγM1, a new available antibody that recognizes the γ chain subunit of the T-cell receptor (TCR) in formalin-fixed paraffin-embedded tissue. Large blast cells were simultaneously positive for TCRαβ and TCRγδ with an activated cytotoxic phenotype. It is worldwide accepted the mutual exclusive expression of TCRαβ and TCRγδ but six different studies, dealing with TCRγδ expression in various types of extra-nodal lymphomas, reported cases whom tumor cells expressed simultaneously TCRαβ and TCRγδ. Our data and those of similar reports, suggest the possibility of existence of a subset of extra-nodal T-cell lymphomas showing simultaneous expression by tumor cells of TCRγδ and TCRαβ with an immunoprofile consistent with an origin from TCRγδ+ T lymphocytes. This unusual subset has...Continue Reading

References

May 29, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·B HaghighiS Kohler
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·David GerberPablo Pereira
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
Jul 18, 2006·Journal of the American Academy of Dermatology·Emmilia HodakMeora Feinmesser
Jul 21, 2007·Journal of Cutaneous Pathology·Witold K JacykLuis Requena
May 23, 2009·American Journal of Clinical Pathology·Michele RoulletJohn K Choi
Jul 21, 2009·Journal of Cutaneous Pathology·Nikki MourtzinosMin-Ling Liu
Oct 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Thomas SerwoldIrving L Weissman
Jul 15, 2011·The American Journal of Surgical Pathology·Adriana Garcia-HerreraAntonio Martinez
Sep 17, 2011·The American Journal of Surgical Pathology·John K C ChanWai-Kong Chan
Jun 23, 2012·The American Journal of Dermatopathology·Werner KempfDario Tomasini
Oct 18, 2012·The American Journal of Surgical Pathology·Joan GuitartYoun H Kim
Jan 26, 2013·The American Journal of Surgical Pathology·Socorro Maria Rodríguez-PinillaMiguel Ángel Piris

❮ Previous
Next ❯

Citations

Feb 23, 2018·The American Journal of Dermatopathology·Maya HijaziOmar Sangueza

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical and Experimental Dermatology
N P Smith
Journal of the European Academy of Dermatology and Venereology : JEADV
O SuC Demirkesen
The British Journal of Dermatology
D SlaterP Corbett
British Medical Journal
S Carne, M Whitehouse
Nederlands tijdschrift voor geneeskunde
© 2022 Meta ULC. All rights reserved