PMID: 9437513Jan 23, 1998Paper

Paget's disease of bone: reduction of disease activity with oral risedronate

Bone
D J HoskingA A Chines

Abstract

Risedronate monosodium [1-hydroxy-2-(3-pyridinyl)ethylidene bisphosphonic acid monosodium salt] is a pyridinyl bisphosphonate drug under development as a treatment for Paget's disease of bone and other metabolic bone disorders. An open-label, single-center study was conducted to determine the efficacy and safety of oral resedronate in patients with severe Paget's disease [mean baseline serum alkaline phosphatase (ALP) about six times the upper limit of normal]. 20 patients (12 men, 8 women; mean age 74 years) were treated with 30 mg/day of oral risedronate for 84 days, followed by 112 days without treatment. This 196 day period was repeated once in 19 patients in whom ALP did not reach the midpoint of the normal range or increased by > or = 25% from the nadir value by the end of the first 196 day period. At the end of the first 196 day period, the mean percentage decrease from baseline in excess ALP and excess urinary hydroxyproline/creatinine (OHP/Cr) was 79.5% and 85.5%, respectively (excess defined as difference between the patient's ALP or OHP/Cr and midpoint of the normal range). At the end of the second period, the decreases were 86.3% and 101.3%, respectively. The decreases in excess ALP and OHP/Cr were significant (p < ...Continue Reading

Citations

Nov 22, 2001·Pharmazie in unserer Zeit·P SchmidK Possinger
Oct 6, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P J Meunier
Feb 25, 2010·Journal of Bone and Mineral Metabolism·Kousei YohJun Hashimoto
Oct 9, 2001·Clinical Therapeutics·E M Umland, E G Boyce
Jul 18, 2000·Journal of the American College of Surgeons·A R Coppes-Zantinga, M J Coppes
Feb 22, 2002·Bone·A A Morales-PigaA Rapado
Sep 17, 2002·Bone·P L SelbyUNKNOWN National Association for the Relief of Paget's Disease
Nov 11, 1999·CAP Today·B Chapman
May 13, 1999·Bone·A GrauerR Ziegler
May 13, 1999·Bone·P D Miller
Mar 16, 2000·British Journal of Clinical Pharmacology·D Y MitchellJ H Powell
Jun 17, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E S SirisP J Bekker
Jan 5, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D C González, C A Mautalen
Mar 30, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C LiH Norimatsu
Apr 1, 2005·Treatments in Endocrinology·Jean-Pierre Devogelaer
Jan 11, 2012·Reumatología clinica·Leticia Lojo Oliveira, Antonio Torrijos Eslava
Jul 8, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Joseph R Tucci
Mar 7, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Satoshi KomatsubaraHiromichi Norimatsu
Sep 10, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elisabeth J SmithEdith M Gardiner
Mar 16, 2001·Expert Opinion on Pharmacotherapy·A Morales-Piga
Feb 22, 2012·Expert Opinion on Pharmacotherapy·Ian R Reid
Jul 5, 2005·Expert Opinion on Investigational Drugs·E J RoldánJ L Ferretti
Jul 13, 2002·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Michael S Gordon, Murray B Gordon
Sep 14, 2010·Bone·Ian R Reid, D J Hosking
Aug 7, 2008·Journal of Veterinary Internal Medicine·M L Frazer
Nov 1, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M AmlingG Karsenty
Dec 19, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·I R Reid
Sep 8, 2016·Wiener medizinische Wochenschrift·Christian MuschitzRoland Kocijan
Jan 9, 2019·Frontiers in Chemistry·Jingjing GuoChaoyong James Yang
Mar 25, 2017·Rheumatology·Stephen Paul TuckRoger Francis
Dec 3, 1999·British Journal of Clinical Pharmacology·D Y MitchellC W Melson
Aug 5, 2004·Clinical Orthopaedics and Related Research·Andrew A SamaJoseph M Lane

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