PMID: 22586699May 16, 2012Paper

Paget's disease of the bone after treatment with Denosumab: a case report

Bone
Peter SchwarzNiklas R Jørgensen

Abstract

Bone affection in Paget's disease is characterized by increased bone turnover localised at one or more sites of the skeleton. Bisphosphonates are the drugs of choice when treating the increased bone turnover in Paget's disease. However, in cases of decreased kidney function only less effective treatments that are available as bisphosphonates are contraindicated in these patients. We present a case of a male patient aged 86 years with GFR of 11 mL/min and Paget's disease successfully treated by Denosumab. The bone turnover and pain decreased upon treatment.

Associated Clinical Trials

Jan 24, 2017·Martin Blomberg Jensen

References


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Citations

Feb 15, 2013·The New England Journal of Medicine·Stuart H Ralston
Jul 3, 2013·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Masamichi Takami
Apr 2, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M Angeles VázquezRamon Pérez-Cano
May 20, 2016·Calcified Tissue International·Ian R ReidCarl Eagleton
Dec 18, 2013·Arquivos brasileiros de endocrinologia e metabologia·Bruno Ferraz-de-Souza, Pedro Henrique Silveira Correa
Feb 26, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Stuart H RalstonStephen P Tuck
Oct 2, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·Emory Hsu
Oct 3, 2020·Zeitschrift für Rheumatologie·P KlemmU Lange
Mar 4, 2017·Clinical Reviews in Bone and Mineral Metabolism·N AlonsoJ Del Pino-Montes
Jun 8, 2018·Nature·Benjamin B SunAdam S Butterworth
Feb 19, 2019·Acta ortopedica brasileira·Felipe Augusto Kazan de OliveiraValter Penna
Mar 25, 2017·Rheumatology·Stephen Paul TuckRoger Francis
Apr 7, 2015·The Journal of Clinical Endocrinology and Metabolism·Mehmet AsikKubilay Ukinc
Apr 7, 2015·The Journal of Clinical Endocrinology and Metabolism·Frederick R SingerEthel S Siris
Oct 4, 2020·International Journal of Surgery Case Reports·Kiyokazu FukuiNorio Kawahara

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