Paget's Disease of the Vulva: A Review of 20 Years' Experience

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Raghava ParashuramaRichard Hutson

Abstract

Extramammary Paget's disease is a rare condition, and the vulva is a common site for it to occur. Despite this, there is a paucity of literature on Paget's disease of the vulva (VPD). A Cochrane meta-analysis could not draw any conclusions on interventions in VPD. Our aim was to review our practice and improve further management of VPD in our center. We reviewed all the cases presented to Leeds Gynaecological Oncology Centre between 1988 and 2016. All cases identified in this interval were followed up until April 2016. All case notes and electronic patient data were retrieved to collate the data. We identified 18 cases of VPD. The median age at presentation was 76.9 years. Primary surgery was used in 18 cases. Eight patients had wide local excision with graft reconstruction. Ten women had wide local excision with primary reconstruction. Margins were negative in 27% of the excisions. Sixty percent of patients with clear surgical margins had a recurrence, and 69% of patients with positive margins had a recurrence; there was no statistical difference between the 2 groups for recurrence (P > 0.05). Fifty-eight percent of patients who had recurrence had coexisting malignancy. Logistic regression showed no correlation of recurrence r...Continue Reading

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Citations

Feb 21, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·Z KangM Guan
Oct 12, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Linda J Rogers, Mauricio A Cuello
Jul 6, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jo MorrisonChristina Fotopoulou
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Sep 15, 2020·Seminars in Diagnostic Pathology·Anastasia M Konstantinova, Dmitry V Kazakov

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