PMID: 9532009Apr 9, 1998Paper

Paget's disease versus Toker cell hyperplasia in a supernumerary nipple

Virchows Archiv : an International Journal of Pathology
M DecaussinL Frappart

Abstract

We report the second case of mammary Paget's disease arising in a supernumerary nipple of a 29-year-old woman. The epithelium of the nipple was infiltrated by large cells with abundant and pale-staining cytoplasm. The nuclei had a vesicular chromatin pattern and identifiable nucleoli. The cells were strongly immunoreactive with KL1, CEA and EMA, but did not show reactivity with PS100, HMB45, or erb-B2. The pathogenesis of Paget cells is unclear. In our case, the lesion showed nearly all the clinical, histological and histochemical characteristics of Paget's disease, though without involvement of mammary gland epithelium and underlying carcinoma. The possibility of an intraepidermal origin, either by transformation from epidermal keratinocytes or by derivation from intraepidermal precursor cells, has to be considered. The differential diagnosis against Toker cell hyperplasia is also discussed.

Citations

Jul 26, 2011·The American Journal of Dermatopathology·Sebastian C J van der Putte
Apr 12, 2003·Journal of Cutaneous Pathology·Joseph H WillmanJames E Fitzpatrick
May 9, 2008·Histopathology·A Fernandez-Flores
Sep 24, 2015·International Journal of Surgery Case Reports·Katherina Zabicki CalvilloSusan C Lester
May 30, 2009·Journal of Cutaneous Pathology·Christine J Ko, Antonio Subtil
Feb 11, 2016·The American Journal of Dermatopathology·Anastasia M KonstantinovaDmitry V Kazakov
Jul 16, 2009·The Breast Journal·Sharon Nofech-Mozes, Wedad Hanna

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