PAI-1-derived peptide EEIIMD prevents hypoxia/ischemia-induced aggravation of endothelin- and thromboxane-induced cerebrovasoconstriction

Neurocritical Care
William M ArmsteadAbd Al-Roof Higazi

Abstract

Babies are frequently exposed to cerebral hypoxia and ischemia (H/I) during the perinatal period as a result of stroke, problems with delivery or post delivery respiratory management. The sole FDA approved treatment for acute stroke is tissue-type plasminogen activator (tPA). Endogenous tPA is upregulated and potentiates impairment of pial artery dilation in response to hypotension after H/I in pigs. Mitogen-activated protein kinase (MAPK), a family of at least 3 kinases, ERK, p38 and JNK, is also upregulated after H/I, with ERK contributing to impaired vasodilation. This study examined the hypothesis that H/I aggravates the vascular response to two important procontractile mediators released during CNS ischemia, endothelin-1 (ET-1) and thromboxane, which is further enhanced by tPA and ERK MAPK. Cerebral hypoxia (pO(2) 35 mmHg for 10 min via inhalation of N(2)) followed immediately by ischemia (global intracranial pressure elevation for 20 min) was produced in chloralose anesthetized piglets equipped with a closed cranial window. H/I aggravated pial artery vasconstriction induced by ET-1 and the thromboxane mimetic U 46619. Potentiated vasoconstrictor responses were blocked by EEIIMD, an inhibitor of tPA's signaling and vascula...Continue Reading

References

Mar 1, 1979·Early Human Development·J Dobbing, J Sands
Jan 1, 1992·Biology of the Neonate·T N Raju
Apr 1, 1989·Stroke; a Journal of Cerebral Circulation·C W LefflerR Mirro
Jul 1, 1987·Journal of Child Neurology·R A Brumback, R W Leech
Aug 1, 1994·Journal of Neurotrauma·T A Gennarelli
Jan 20, 1994·The New England Journal of Medicine·K C Kuban, A Leviton
Mar 1, 1993·Seminars in Neurology·M J Rivkin, J J Volpe
Jun 1, 1997·British Journal of Obstetrics and Gynaecology·L D Longo, S Packianathan
Feb 11, 1998·Physiological Reviews·F M Faraci, D D Heistad
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·A AlessandriniJ V Bonventre
Oct 7, 2000·Stroke; a Journal of Cerebral Circulation·G GüntherUNKNOWN Childhood Stroke Study Group
Aug 7, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I Laher, J H Zhang
Aug 11, 2001·The New England Journal of Medicine·G deVeberUNKNOWN Canadian Pediatric Ischemic Stroke Study Group
Aug 13, 2002·The Journal of Biological Chemistry·Taher NassarAbd Al-Roof Higazi
Dec 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Amanda L Jagolino, William M Armstead
Feb 26, 2004·Lancet Neurology·Karin B Nelson, John K Lynch
Mar 6, 2004·Journal of Neurotrauma·Jonathan Ford, William M Armstead
Nov 5, 2004·The New England Journal of Medicine·Donna M Ferriero
Aug 16, 2005·Brain Research. Developmental Brain Research·William M ArmsteadAbd Al-Roof Higazie
Apr 14, 2007·Stroke; a Journal of Cerebral Circulation·Nazli JanjuaAdnan I Qureshi
Jul 11, 2007·Journal of Child Neurology·Susan L BenedictJames F Bale
Jul 29, 2008·Brain Research·William M ArmsteadAbd Al-Roof Higazi
May 14, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·William M ArmsteadVladimir R Muzykantov
May 4, 2010·American Journal of Physiology. Heart and Circulatory Physiology·William M ArmsteadAbd Al-Roof Higazi
Nov 13, 2010·Cardiovascular Therapeutics·William M Armstead

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