PAI-1 expression in intratumoral inflammatory infiltrate contributes to lymph node metastasis in oral cancer: A cross-sectional study.

Annals of Medicine and Surgery
Mayara Mota de OliveiraAdriana Madeira Álvares da Silva

Abstract

Immune cells contribute with mediators in the protein expression profile of the tumor microenvironment. Levels of plasminogen activator inhibitor-1 (PAI-1) are elevated in non-malignant inflammatory conditions; however, the association between PAI-1 expression and inflammation remains uncertain in oral squamous cell carcinoma (OSCC). This study aimed to investigate PAI-1 expression in mononuclear inflammatory cell infiltrate in OSCC and its role as a prognostic marker. Samples were collected from patients with OSCC, treated surgically, and followed for 24 months after the procedure. Thirty-nine tumoral tissue were analyzed using immunohistochemistry. Correlation between protein expression, clinicopathological parameters, and the prognosis was investigated. Positive PAI-1 expression in mononuclear inflammatory cell infiltrate was significantly associated with lymph node status (p = 0.009) and with the cytoplasmic expression of vascular endothelial growth factor A (VEGFA) (p = 0.028). Multivariate analysis revealed weak PAI-1 expression as an independent marker for lymph node metastases, with approximately 8-fold increased risk compared to strong expression (OR = 8.60; CI = 1.54-48.08; p = 0.014). Our results suggest that the str...Continue Reading

References

Oct 7, 1998·International Journal of Cancer. Journal International Du Cancer·S K ChambersM L Carcangiu
Jan 7, 2004·Nature Reviews. Cancer·Jeffrey W Pollard
Apr 7, 2005·Journal of Clinical Periodontology·Nurcan BuduneliDenis F Kinane
Aug 5, 2006·Molecular Pharmacology·Qingdong Ke, Max Costa
Dec 29, 2007·Cancer Treatment Reviews·Kathleen DassFazlul H Sarkar
May 23, 2008·Immunology Letters·Bernd R Binder, Judit Mihaly
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Jul 16, 2010·Developmental Cell·Mikala EgebladZena Werb
May 20, 2011·Nature·Peter Carmeliet, Rakesh K Jain
Oct 3, 2012·PloS One·Marcelo dos SantosAdriana Madeira Álvares da Silva
Mar 16, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N HarbeckUNKNOWN Chemo-N 0 Study Group
Nov 26, 2013·Oral Oncology·Heng-Wei HsuSaied Mirshahidi
Jan 28, 2014·Molecular Cancer Research : MCR·Evan Gomes GiacoiaCharles J Rosser
Jan 30, 2014·Brazilian Journal of Otorhinolaryngology·Ali AmarLenine Garcia Brandão
Jul 5, 2015·Brazilian Journal of Otorhinolaryngology·Vivian Regina AffonsoRui Celso Martins Mamede
Jul 15, 2015·Nature Reviews. Cancer·Doris P Tabassum, Kornelia Polyak
Sep 25, 2015·Genetics and Molecular Research : GMR·G T PeterleA M A Silva-Conforti
Aug 8, 2017·Nature·Dan R RobinsonArul M Chinnaiyan
Apr 26, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Gabriela Tonini PeterleAdriana Madeira Álvares da Silva
Jun 1, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sijing LiLi Sun
Oct 24, 2018·International Journal of Cancer. Journal International Du Cancer·J FerlayF Bray
Nov 18, 2019·Cancer Metastasis Reviews·Marta Helena Kubala, Yves Albert DeClerck

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