PAI-1, progress in understanding the clinical problem and its aetiology

British Journal of Haematology
T IwakiK Umemura

Abstract

Plasminogen activator inhibitor-1 (PAI-1, also known as SERPINE1) is a member of the serine protease inhibitor (SERPIN) superfamily and is the primary physiological regulator of urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA) activity. Although the principal function of PAI-1 is the inhibition of fibrinolysis, PAI-1 possesses pleiotropic functions besides haemostasis. In the quarter century since its discovery, a number of studies have focused on improving our understanding of PAI-1 functions in vivo and in vitro. The use of Serpine1-deficient mice has particularly enhanced our understanding of the functions of PAI-1 in various physiological and pathophysiological conditions. In this review, the results of recent studies on PAI-1 and its role in clinical conditions are discussed.

References

Jan 1, 1992·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·W E ScalesS L Kunkel
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J SchneidermanD J Loskutoff
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J A PiedrahitaN Maeda
May 1, 1989·The Journal of Clinical Investigation·R R SchleefL J Levitt
Dec 1, 1989·The Journal of Cell Biology·P JonesD R Critchley
Nov 11, 1989·Nucleic Acids Research·J MimuroD J Luskutoff
Jan 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A BiniK L Kaplan
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T NyD J Loskutoff
Jul 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·F LupuE K Kruithof
Nov 1, 1996·Circulation·H R Lijnen, D Collen
Dec 10, 1999·The Urologic Clinics of North America·V Lazaron, R A Barke
Apr 15, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·P E MorangeI Juhan-Vague
Mar 21, 2001·Cellular Signalling·M Guha, N Mackman
Aug 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K SchäferD J Loskutoff
Jan 16, 2002·Current Opinion in Immunology·Andrew D Luster
Jul 12, 2002·American Journal of Physiology. Renal Physiology·Allison A Eddy
Jan 14, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·H Roger LijnenMarie-Christine Alessi
Jun 24, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jordan D SavovDavid A Schwartz
Jan 22, 2004·Experimental Biology and Medicine·Seong H ChoChad K Oh
Mar 12, 2004·Thrombosis Research·Iwona KucharewiczAnna Bodzenta-Łukaszyk

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Citations

Oct 5, 2013·Journal of Mammary Gland Biology and Neoplasia·Nikki A FordStephen D Hursting
Nov 28, 2013·Cancer & Metabolism·Stephen D HurstingLaura M Lashinger
Sep 7, 2012·PloS One·Alexandre MarchandDavid-Alexandre Trégouët
May 3, 2013·Journal of Periodontology·Francesco D'AiutoJohn C Gunsolley
May 13, 2015·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·P ElkanP Gerdhem
Jan 18, 2016·Trends in Parasitology·Javier González-MiguelFernando Simón
Apr 11, 2014·Thrombosis and Haemostasis·E K O Kruithof, S Dunoyer-Geindre
Aug 27, 2015·Science Signaling·Kevin WilhelmsenJudith Hellman
May 3, 2013·Journal of Clinical Periodontology·Francesco D'AiutoJohn C Gunsolley
Nov 18, 2014·Journal of Thrombosis and Haemostasis : JTH·R Teruel-MontoyaC Martínez
Mar 26, 2013·Expert Opinion on Therapeutic Patents·Yolanda M Fortenberry
Jul 8, 2015·Brain Research Bulletin·Yi-Yen LeeMing-Teh Chen
Mar 6, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Chiné PieterseAletta E Schutte
Jul 2, 2016·Journal of Laboratory Physicians·Suheyla GorarYalcin Aral
Jun 6, 2013·Current Opinion in Pharmacology·Michael SchuligaAlastair G Stewart
Apr 17, 2015·Mediators of Inflammation·Michael Schuliga
Oct 9, 2014·Blood Reviews·John C Chapin, Katherine A Hajjar
Jun 12, 2016·Journal of Pharmaceutical and Biomedical Analysis·Catalina Cioates NegutDenisa Ioana Udeanu
Dec 16, 2016·Thrombosis and Haemostasis·Max-Paul WinterAlexander Niessner
Sep 2, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Charles J GlueckPing Wang
Jun 22, 2017·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Anna Janina EngstlerIna Bergheim
May 21, 2018·Journal of Thrombosis and Haemostasis : JTH·T UranoY Suzuki
May 31, 2018·Journal of Thrombosis and Haemostasis : JTH·J L SaesM R Nijziel
Feb 18, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lucie AumailleyMichel Lebel
Jul 21, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Stephen D Hursting, Marcie J Hursting
Oct 5, 2016·Journal of the American Heart Association·Nuri KodamanScott M Williams

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