Pain After Spinal Cord Injury Is Associated With Abnormal Presynaptic Inhibition in the Posterior Nucleus of the Thalamus

The Journal of Pain : Official Journal of the American Pain Society
Anthony ParkAsaf Keller

Abstract

Pain after spinal cord injury (SCI-Pain) is one of the most debilitating sequelae of spinal cord injury, characterized as relentless, excruciating pain that is largely refractory to treatments. Although it is generally agreed that SCI-Pain results from maladaptive plasticity in the pain processing pathway that includes the spinothalamic tract and somatosensory thalamus, the specific mechanisms underlying the development and maintenance of such pain are yet unclear. However, accumulating evidence suggests that SCI-Pain may be causally related to abnormal thalamic disinhibition, leading to hyperactivity in the posterior thalamic nucleus (PO), a higher-order nucleus involved in somatosensory and pain processing. We previously described several presynaptic mechanisms by which activity in PO is regulated, including the regulation of GABAergic as well as glutamatergic release by presynaptic metabotropic gamma-aminobutyric acid (GABAB) receptors. Using acute slices from a mouse model of SCI-Pain, we tested whether such mechanisms are affected by SCI-Pain. We reveal 2 abnormal changes in presynaptic signaling in the SCI-Pain condition. The substantial tonic activation of presynaptic GABAB receptors on GABAergic projections to PO-charac...Continue Reading

References

Feb 13, 1980·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·N J BirdsallA Burgen
Jan 1, 1984·Anatomy and Embryology·O P Ottersen, J Storm-Mathisen
Aug 18, 1995·Journal of Medicinal Chemistry·W FroestlH R Olpe
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Oct 1, 1996·Journal of Pain and Symptom Management·P G Loubser, N M Akman
Jan 1, 1997·Brain Research Bulletin·P ArcelliR Spreafico
Oct 10, 1998·Neurologic Clinics·A Berić
Nov 28, 2000·Spinal Cord·A RavenscroftI G Burnside
Dec 1, 2000·Progress in Brain Research·R P Yezierski
Oct 30, 2001·Behavioural Brain Research·S G Wilson, J S Mogil
Feb 5, 2002·Annual Review of Physiology·Robert S Zucker, Wade G Regehr
Jun 6, 2002·The Clinical Journal of Pain·Catherine A WarmsDiana D Cardenas
Oct 18, 2002·The European Journal of Neuroscience·P BarthóL Acsády
May 15, 2003·Somatosensory & Motor Research·N B FinnerupT S Jensen
Mar 1, 1961·Experimental Neurology·E R PERL, D G WHITLOCK
Mar 1, 1961·Experimental Neurology·D G WHITLOCK, E R PERL
Jan 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Caroline Gauriau, Jean-François Bernard
Feb 7, 2004·Acta Neurologica Scandinavica·N B FinnerupT S Jensen
Oct 8, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason C Trageser, Asaf Keller
Mar 31, 2005·Neuron·Hajnalka BokorLászló Acsády
Aug 19, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philippe LavalléeMartin Deschênes
Nov 4, 2005·Experimental Neurology·Charles H Hubscher, Richard D Johnson
Jun 16, 2006·Journal of Neurophysiology·Jason C TrageserAsaf Keller
Jun 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·A S KozlovS Charpak
Jul 28, 2006·Journal of Neurophysiology·Radi MasriAsaf Keller

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