Pain and autonomic dysfunction in patients with sarcoidosis and small fibre neuropathy.

Journal of Neurology
M BakkersI S J Merkies

Abstract

Small fibre neuropathy (SFN) has been demonstrated in sarcoidosis. However, a systematic analysis of neuropathic pain and autonomic symptoms, key features of SFN, has not been performed. Clinimetric evaluation of pain and autonomic symptoms using the neuropathic pain scale (NPS) and the modified Composite Autonomic Symptoms Scale (mCOMPASS) was used in sarcoidosis patients for this study. A total of 91 sarcoidosis patients (n = 23 without SFN symptoms, n = 43 with SFN symptoms but normal intraepidermal nerve fibre density (IENFD), n = 25 with SFN symptoms and reduced IENFD) were examined. NPS and mCOMPASS were assessed twice (reliability studies). Severity of pain was compared between the subgroups. Correlation between NPS and a visual analogue pain scale (VAS) was assessed (validity studies). Healthy controls (n = 105) completed the mCOMPASS for comparison with patients' scores. Patients with sarcoidosis, SFN complaints, and reduced IENFD demonstrated more severe pain scores on the NPS. The mCOMPASS differentiated between subjects with and without SFN symptoms. A significant correlation was obtained between the NPS and VAS, indicating good construct validity. Good reliability values were obtained for all scales. The use of the...Continue Reading

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Citations

Feb 8, 2011·Current Pain and Headache Reports·Jinny Tavee, Daniel Culver
Oct 10, 2014·Continuum : Lifelong Learning in Neurology·Christopher H Gibbons
Feb 22, 2014·Expert Opinion on Investigational Drugs·Monique van VelzenMichael Brines
Jan 11, 2013·Pain Research and Treatment·Lara HeijElske Hoitsma
Jan 4, 2013·Journal of the Peripheral Nervous System : JPNS·Giuseppe Lauria, Raffaella Lombardi
Feb 24, 2015·Neuroscience Letters·Ingemar S J MerkiesGiuseppe Lauria
May 7, 2016·PloS One·Maren ReimerJanne Gierthmühlen
Nov 1, 2017·Annals of the American Thoracic Society·Alicia K GerkeLaura L Koth
Jul 14, 2018·Current Opinion in Pulmonary Medicine·Vasileios KouranosSimon Walsh
Dec 21, 2018·Journal of the Peripheral Nervous System : JPNS·Maurice SopacuaCatharina G Faber
Feb 7, 2018·Therapeutic Advances in Neurological Disorders·Xiaolei LiuAnne Louise Oaklander
Dec 19, 2020·Journal of Neuromuscular Diseases·Lisette R M RaasingJan C Grutters

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Methods Mentioned

BETA
biopsy

Software Mentioned

Teleform
mCOMPASS

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