Pain and mean absorbed dose to the pubic bone after radiotherapy among gynecological cancer survivors

International Journal of Radiation Oncology, Biology, Physics
Ann-Charlotte WaldenströmGunnar Steineck

Abstract

To analyze the relationship between mean absorbed dose to the pubic bone after pelvic radiotherapy for gynecological cancer and occurrence of pubic bone pain among long-term survivors. In an unselected, population-based study, we identified 823 long-term gynecological cancer survivors treated with pelvic radiotherapy during 1991-2003. For comparison, we used a non-radiation-treated control population of 478 matched women from the Swedish Population Register. Pain, intensity of pain, and functional impairment due to pain in the pubic bone were assessed with a study-specific postal questionnaire. We analyzed data from 650 survivors (participation rate 79%) with median follow-up of 6.3 years (range, 2.3-15.0 years) along with 344 control women (participation rate, 72 %). Ten percent of the survivors were treated with radiotherapy; ninety percent with surgery plus radiotherapy. Brachytherapy was added in 81%. Complete treatment records were recovered for 538/650 survivors, with dose distribution data including dose-volume histograms over the pubic bone. Pubic bone pain was reported by 73 survivors (11%); 59/517 (11%) had been exposed to mean absorbed external beam doses <52.5 Gy to the pubic bone and 5/12 (42%) to mean absorbed ext...Continue Reading

References

Jun 1, 1994·American Journal of Clinical Oncology·A L FuY Maruyama
Nov 1, 1996·AJR. American Journal of Roentgenology·V BlomlieH H Lien
Apr 29, 1999·International Journal of Radiation Oncology, Biology, Physics·A MorenoF J Andreu
May 6, 1999·The New England Journal of Medicine·K BergmarkG Steineck
Jun 28, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P TaiJ Radwan
Aug 28, 2002·Acta Oncologica·Gunnar SteineckAsgeir Helgason
Sep 13, 2002·The New England Journal of Medicine·Gunnar SteineckUNKNOWN Scandinavian Prostatic Cancer Group Study Number 4
Jul 30, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ichiro OginoHiroki Nakayama
Sep 15, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Olof Johnell, John Kanis
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·D FeltlJ Kubes
Oct 9, 2007·International Journal of Radiation Oncology, Biology, Physics·Dongryul OhJe Ho Lee
Sep 23, 2008·AJR. American Journal of Roentgenology·Jong Won KwonBong Keun Choe
Nov 21, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Gail DunbergerElisabeth Vall-Lundqvist
Apr 20, 2010·Acta Oncologica·Ann-Charlotte WaldenströmMarkus Müller

❮ Previous
Next ❯

Citations

Jul 3, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Gail DunbergerElisabeth Åvall-Lundqvist
Mar 29, 2014·Practical Radiation Oncology·Tracy S BrayJohn C Roeske
Mar 1, 2012·International Journal of Radiation Oncology, Biology, Physics·Ann-Charlotte WaldenströmGunnar Steineck
Nov 15, 2011·International Journal of Radiation Oncology, Biology, Physics·Dan LundstedtPer Karlsson
Mar 15, 2015·International Journal of Radiation Oncology, Biology, Physics·Dan LundstedtPer Karlsson
Feb 11, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Dan LundstedtPer Karlsson
Apr 27, 2016·Journal of Pain and Symptom Management·Marieke H J van den Beuken-van EverdingenDaisy J A Janssen
Jan 27, 2018·Journal of Adolescent and Young Adult Oncology·Maria OlssonMarianne Jarfelt
Mar 7, 2018·Journal of Cancer Survivorship : Research and Practice·Maria OlssonMarianne Jarfelt
Oct 1, 2018·Pain Practice : the Official Journal of World Institute of Pain·Laurence LeysenDavid Beckwée
Jan 26, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Pratibha NayakLinda S Elting
Dec 13, 2019·Journal of Cancer Survivorship : Research and Practice·Emily Cox-MartinCathy Bradley
Jan 17, 2012·Current Opinion in Supportive and Palliative Care·Gail Dunberger, Karin Bergmark
Mar 17, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Yolanda RibasH Jervoise Andreyev

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Dan LundstedtPer Karlsson
The New England Journal of Medicine
K BergmarkGunnar Steineck
International Journal of Radiation Oncology, Biology, Physics
Dongryul OhJe Ho Lee
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Ichiro OginoHiroki Nakayama
© 2021 Meta ULC. All rights reserved