Pain and mechanical properties of the rectum in patients with active ulcerative colitis

Inflammatory Bowel Diseases
A M DrewesH Gregersen

Abstract

The pain, urgency, and incontinence in ulcerative colitis may be related to changes in viscoelastic properties of the gut wall or to alterations of the sensory pathways. In the present study, we used an advanced rectal probe to study the mechanosensory and smooth muscle properties in patients with active disease. Nine patients with ulcerative colitis (mean age 39.5 years) with exacerbation limited to the rectum and sigmoid colon and 17 age-matched healthy subjects were included. The rectum was distended before and after pharmacological relaxation of the smooth muscle until moderate pain was reported, and the cross-sectional area, volume, pressure, tension, and strain were computed. To investigate central integration of a tonic stimulus, the bag was finally distended to the pain threshold; then, the cross-sectional area was held constant for 2 min. The patients were hypersensitive to mechanical stimuli as assessed by the cross-sectional area (F = 21.7; P < 0.001). There were no differences in compliance or stiffness between the 2 groups, but the hypersensitivity was abolished after muscle relaxation. Together with the muscle analysis, this finding demonstrated that the smooth muscles were tonically contracted in the inflamed rec...Continue Reading

References

Feb 1, 1994·Psychological Reports·G Frank
Dec 1, 1996·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H Gregersen, G Kassab
Mar 4, 2000·European Journal of Pain : EJP·M A Giamberardino
Dec 1, 2000·Progress in Brain Research·L Arendt-NielsenA M Drewes
Mar 19, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·J D BarlowD G Thompson
Jun 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Asbjørn Mohr DrewesLars Arendt-Nielsen
Oct 4, 2002·European Journal of Gastroenterology & Hepatology·Jürgen M GschossmannGerald Holtmann
Nov 15, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Chunwen GaoHans Gregersen
Jan 16, 2003·European Journal of Pain : EJP·Asbjørn M DrewesLars Arendt-Nielsen
Jul 12, 2003·Pain·Asbjørn Mohr DrewesLars Arendt-Nielsen
Jul 23, 2003·Digestive Diseases and Sciences·Poul PetersenAsbjørn Mohr Drewes
Dec 23, 2003·Scandinavian Journal of Gastroenterology·A M DrewesL Arendt-Nielsen
Sep 25, 2004·Digestive Diseases and Sciences·Jan PedersenAsbjørn Mohr Drewes
Dec 17, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T TakedaR K Mittal
Jul 5, 2005·The Journal of Pain : Official Journal of the American Pain Society·Asbjørn Mohr DrewesSøren Lundbye-Christensen
Jul 23, 2005·World Journal of Gastroenterology : WJG·Asbjørn-Mohr DrewesHans Gregersen
Aug 5, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J B FrøkjaerH Gregersen
Jan 1, 2003·Scandinavian Journal of Gastroenterology·A M DrcwesH Gregersen

❮ Previous
Next ❯

Citations

Jan 9, 2009·Inflammatory Bowel Diseases·Klaus BielefeldtDavid G Binion
Jul 9, 2008·World Journal of Gastroenterology : WJG·Asbjørn M DrewesLars Arendt-Nielsen
Jan 6, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A M HaaseK Krogh
Sep 20, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Christina BrockAsbjørn Mohr Drewes
Mar 7, 2009·Journal of Biomechanics·Jian YangHans Gregersen
May 17, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C BrockA M Drewes
Mar 30, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J B FrøkjaerH Gregersen
Nov 14, 2013·Pain Practice : the Official Journal of World Institute of Pain·Frederik L KristiansenAsbjørn M Drewes
Sep 17, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J FassovK Krogh
Apr 23, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S HaasA M Drewes
May 27, 2015·Pain Practice : the Official Journal of World Institute of Pain·Jacob JuelAsbjørn M Drewes
Apr 24, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S HaasS Laurberg
Jan 22, 2009·Pain·Charles H Knowles, Qasim Aziz
Apr 6, 2007·Gastroenterology·Georg DimcevskiAsbjørn M Drewes
May 5, 2017·Alimentary Pharmacology & Therapeutics·C NortonA Hart
Aug 21, 2013·Inflammatory Bowel Diseases·Athanasios PapathanasopoulosEpameinondas V Tsianos
Apr 3, 2018·Journal of Neurogastroenterology and Motility·Hans Gregersen, Kar Man Lo
Jul 9, 2014·Nature Reviews. Gastroenterology & Hepatology·Stuart M Brierley, David R Linden
Mar 8, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Walter E B SipeNigel W Bunnett
May 25, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Thomas Dahl NissenAsbjørn Mohr Drewes
Jan 31, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Simona E Carbone, Daniel P Poole
Jul 9, 2020·Clinical and Experimental Gastroenterology·Janne FassovKlaus Krogh
Jan 13, 2015·World Journal of Gastroenterology : WJG·Stefan A W BouwenseOliver H G Wilder-Smith
Oct 22, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Liya Y Qiao, Namrata Tiwari
Feb 12, 2019·Cellular and Molecular Gastroenterology and Hepatology·Wilmarie Morales-Soto, Brian D Gulbransen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.