Pain and pain generation in pancreatic cancer

Langenbeck's Archives of Surgery
Fabio F di Mola, Pierluigi di Sebastiano

Abstract

Pain can be a frequent symptom during the natural history of a patient with pancreatic cancer. An increase in incidence with disease progression and the presence of unbearable pain may preclude a curative resection. Even in those patients with resectable pancreatic cancer, the presence of pain has an impact on prognosis. To date, we do not really know why some patients develop pain. Perineural cancer cell invasion is one of the most intriguing characteristics of this neoplasia and may in some cases explain the pain sensation. In addition, so-called "neurogenic inflammation" might also play a role in pain generation in pancreatic cancer, just like in chronic pancreatitis. In conclusion, understanding the mechanisms of pain in pancreatic cancer could help patients because what counts is not only 5-year survival but also median survival with good quality of life.

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Citations

Sep 24, 2011·Nature Reviews. Cancer·Aditi A BapatHaiyong Han
Oct 24, 2013·World Journal of Gastroenterology : WJG·Jun YaoShe-Gan Gao
Jan 23, 2016·Biochimica Et Biophysica Acta·Dingkong LiangXianjun Yu
Nov 28, 2009·Best Practice & Research. Clinical Gastroenterology·Pierluigi di SebastianoFabio F di Mola
Oct 16, 2015·Nature Reviews. Gastroenterology & Hepatology·Ihsan Ekin DemirGüralp O Ceyhan
Jun 30, 2019·Cancers·Giulia GaspariniMassimo Falconi
Jun 16, 2015·World Journal of Gastroenterology : WJG·Hui-Lin YeRu-Fu Chen
Feb 24, 2017·Digestive Diseases and Sciences·Andreas I KoulourisAndrew R Hart
Feb 13, 2018·Immunological Reviews·Kalpna Gupta, Ilkka T Harvima
Jan 3, 2021·Current Treatment Options in Oncology·Kristina G LeeAndrew E Hendifar

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