Pain and u-shaped dose responses: occurrence, mechanisms, and clinical implications

Critical Reviews in Toxicology
Edward J Calabrese

Abstract

This article assesses pain within the context of the dose response. A substantial number of studies indicate that the dose response for pain-related endpoints is commonly biphasic, being independent of the type of biological model employed, endpoint measured, or agent tested. The quantitative features of the dose response are also remarkably consistent regardless of the receptor pathway that mediates the nociceptive response, indicating a likely downstream message convergence. These findings have important implications for drug discovery, development, and clinical evaluation.

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Citations

Apr 4, 2013·Antioxidants & Redox Signaling·Carolin CorneliusSalvatore Cuzzocrea
Apr 13, 2011·Journal of Cell Communication and Signaling·Edward J Calabrese, Mark P Mattson
Mar 25, 2010·Human & Experimental Toxicology·Edward J Calabrese
Nov 7, 2015·Immunity & Ageing : I & a·Sandro DattiloVittorio Calabrese
Apr 15, 2015·Homeopathy : the Journal of the Faculty of Homeopathy·Andrea Dei, Simonetta Bernardini
Oct 19, 2016·Journal of Neuroscience Research·V CalabreseE J Calabrese
Feb 20, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sylvain AuvityNicolas Tournier
Mar 18, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Fernanda PetryLiz G Müller
Jan 12, 2021·Annual Review of Food Science and Technology·Edward J Calabrese
Jan 1, 2017·Brain Circulation·Edward J CalabreseJames Giordano

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