PMID: 8951927Oct 1, 1996Paper

Pain control after dental surgery: a double-blind, randomised trial of lornoxicam versus morphine

Pain
Sven E NørholtA K Ersbøll

Abstract

Lornoxicam is a new non-steroidal anti-inflammatory drug of the oxicam class. This randomised, double-blind, placebo controlled trial compared the analgesic efficacy and tolerability of intramuscular (IM) injections of lornoxicam (4, 8, 16 and 20 mg) with morphine (10 and 20 mg) and placebo in 252 patients with mainly moderate to severe pain following surgical removal of an impacted mandibular third molar. Patients treated with lornoxicam or morphine experienced a significantly greater cumulative pain relief over the 4-h post-injection period (TOTPAR0-4) than placebo recipients. This effect appeared to be dose-dependent, with patients in the lornoxicam 4 mg or morphine 10 mg groups recording significantly lower TOTPAR0-4 scores than patients in the higher dosage groups of these drugs. No significant difference was detected between the morphine 20 mg group and the lornoxicam 8, 16 and 20 mg groups. Lornoxicam was well tolerated at all doses and was associated with a significantly lower incidence of adverse events than morphine 10 or 20 mg. Thus, the analgesic efficacy of IM lornoxicam at doses > or = 4 mg is superior to placebo, and doses > or = 8 mg are at least as effective as IM morphine 20 mg. Furthermore, lornoxicam possess...Continue Reading

Associated Clinical Trials

References

Jun 1, 1989·Clinical Pharmacology and Therapeutics·G J LavigneR A Dionne
Oct 1, 1988·Postgraduate Medical Journal·S I AnkierH P Ferber
May 20, 1988·The American Journal of Medicine·P J Desjardins
Jan 1, 1983·Journal of Clinical Pharmacology·P Y GrabinskiR W Houde
Dec 1, 1981·British Journal of Anaesthesia·G W HanksT Trueman

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Citations

Mar 4, 2011·European Journal of Clinical Pharmacology·Mohamed Daabiss, Mohamed Hashish
Dec 2, 2010·Oral and Maxillofacial Surgery·Francine D LustenbergerTill S Mutzbauer
Mar 18, 2009·Hernia : the Journal of Hernias and Abdominal Wall Surgery·O Mentes, M Bagci
Nov 14, 2007·International Urology and Nephrology·Gonul OlmezHayrettin Sahin
Jan 16, 2014·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Sudip Kr DasShubhrakanti Sen
Mar 31, 1999·Journal of Pain and Symptom Management·H J McQuayR A Moore
Aug 6, 1999·Journal of Clinical Pharmacology·H StaunstrupK Krøner
Mar 26, 2014·Saudi Journal of Anaesthesia·Ashraf A AbdelhalimMohamed Moustafa
Dec 18, 2007·Journal of Clinical Anesthesia·Kerem InanogluAlper Kararmaz
Jul 28, 2006·British Journal of Clinical Pharmacology·Henry J McQuay, R Andrew Moore
Apr 22, 2011·Pain Practice : the Official Journal of World Institute of Pain·Luis E ChaparroWilliam Joaqui
Dec 18, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Zeynep Fatma ZorSedat Cetiner
Mar 1, 2005·Current Therapeutic Research, Clinical and Experimental·Bahadir DaglarCelalettin Kayiran
May 13, 2008·European Journal of Anaesthesiology·M FelfernigD Felfernig
Mar 29, 2001·Anesthesia and Analgesia·E R BastoL P Jacob

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