Pain discomfort and crevicular fluid changes induced by orthodontic elastic separators in children

The Journal of Pain : Official Journal of the American Pain Society
Catherine GiannopoulouStavros Kiliaridis

Abstract

The objective of the present investigation was to study the experience of pain after placement of orthodontic elastic separators and the possible associations with the gingival crevicular fluid (GCF) composition changes at the level of interleukin 1-beta (IL-1beta), substance P (SP), and prostaglandin-E2 (PGE2). Eighteen children (mean age 10.8 yrs) in the beginning of the orthodontic treatment were included. Molar elastic separators were inserted mesially to 2 first upper or lower molars. One of the antagonist molars served as control. The GCF was collected from the distobuccal and distopalatal sites from each molar, before (day -7, day 0) and after the placement of separators (1 h, day 1, and day 7). Pain intensity was recorded using a visual analog scale (VAS). The contents of IL-1beta, SP, and PGE2 were determined by enzyme-linked immunosorbent assay. Pain intensity increased after 1 h (VAS = 11) and remained high on day 1 (VAS = 13). On day 7, no significant pain was reported. After 1 h, 1 day, and 7 days, mean GCF IL-1beta levels were significantly elevated at treatment teeth compared to control teeth (highest day 1). The GCF levels of SP and PGE2 for the treatment teeth were significantly higher at day 1 and day 7 than t...Continue Reading

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Citations

Apr 20, 2011·Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie·Sandra LehnenMartin Baxmann
Jul 12, 2011·Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie·Sandra LehnenMartin Baxmann
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