PMID: 8733302Apr 26, 1996

Pain due to tissue acidosis: a mechanism for inflammatory and ischemic myalgia?

Neuroscience Letters
U IssbernerKay H Steen


To study the role of protons in ischemic muscle pain we employed the "submaximal effort tourniquet technique' and, in a second attempt, an intramuscular pressure infusion of acid phosphate buffer. The pH measured in the forearm skin covering the muscles at work during the tourniquet test continuously dropped to a mean value of pH 7.00 +/- 0.26, starting 1 min after the contractions, while the pain increased in direct correlation with the hydrogen ion concentration (r = 0.96). After restoring the blood supply, the intradermal proton concentration decreased more slowly than the muscular pain. The same subjective quality of deep muscular pain was achieved with pressure infusion of acid phosphate buffer (pH 5.2) into the forearm muscles. Constant flow rates evoked constant, apparently non-adapting magnitudes of pain with a log-linear stimulus-response relationship (r = 0.93). Changes in flow rate were followed by changes in pain ratings with a certain phase lag. We conclude that muscular pain induced by infusion of acidic phosphate buffer and pain from ischemic contractions are generated through the same mechanisms based on the algogenic action of protons.


Oct 1, 1988·The Journal of Clinical Investigation·R G VictorR L Nunnally
Feb 18, 1985·Brain Research·R KanakaR F Schmidt
Jun 7, 1974·Brain Research·Siegfried Mense, R F Schmidt
Oct 1, 1994·Journal of Pain and Symptom Management·H J Waldman


Jan 14, 2009·Experimental Brain Research·Siegfried Mense
Feb 25, 2005·Journal of Neurology·F Birklein
Nov 20, 2001·Current Opinion in Pharmacology·P W Reeh, M Kress
Nov 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Chia-Ching John LinChih-Cheng Chen
Sep 26, 2009·The Journal of Biological Chemistry·Miguel SalinasEric Lingueglia
May 19, 2011·The Journal of Biological Chemistry·Ye YuTian-Le Xu
Sep 2, 2009·The Journal of General Physiology·Beiying LiuFeng Qin
May 8, 2004·Antioxidants & Redox Signaling·Valery V KhramtsovDavid J Lurie
Apr 6, 2001·The Clinical Journal of Pain·Thomas Graven-Nielsen, Siegfried Mense
Apr 1, 1999·Annual Review of Physiology·Edwin W McCleskey, M S Gold
Sep 21, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Jiahao LiuJianhua Li
Feb 29, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lynn A BurnesKathleen A Sluka
Feb 19, 2010·American Journal of Physiology. Renal Physiology·Kimberly CorrowMargaret A Vizzard
Oct 24, 2002·The Journal of Clinical Investigation·Shinya UgawaShoichi Shimada
Mar 31, 2009·Journal of Dental Research·R Ambalavanar, D Dessem
Nov 2, 2012·The Journal of Manual & Manipulative Therapy·Lars Arendt-NielsenThomas Graven-Nielsen
Dec 10, 2013·Arthritis Research & Therapy·Josimari M DeSantanaKathleen A Sluka
Mar 13, 2014·PloS One·Naghmeh Hajarol AsvadiPeter J Cabot
Dec 2, 2004·Sports Medicine·Andrew C Bulmer, Jeff S Coombes
Mar 19, 2014·Journal of the International Society of Sports Nutrition·Thapanee RoengritNaruemon Leelayuwat
Jun 21, 2014·Biologie aujourd'hui·Eric Lingueglia
Apr 10, 2014·Sports Medicine·Brendan R ScottBen J Dascombe
May 14, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·M Anthony CometaAndré P Boezaart
Jan 12, 2012·Pharmacology & Therapeutics·Wei-Li WuChih-Cheng Chen
Mar 27, 2015·European Journal of Pain : EJP·H SatoP Svensson
Mar 27, 2010·The Journal of Pain : Official Journal of the American Pain Society·Hyoung-Sig SeoJang-Hern Lee
Dec 27, 2008·European Journal of Pharmacology·Héctor I Rocha-GonzálezVinicio Granados-Soto
Aug 10, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Sinyoung KangTimothy J Brennan
Apr 21, 2012·The European Journal of Neuroscience·Li-Hua HangJian-Ling Zuo
May 8, 2013·European Journal of Pain : EJP·E E CastrillonM Ernberg
Dec 19, 2006·European Journal of Pain : EJP·Janne LudwigRalf Baron
May 21, 2015·Journal of Plastic Surgery and Hand Surgery·Trine I SkarsvågVilhjalmur Finsen
Jan 1, 2008·Archives of Physical Medicine and Rehabilitation·Jay P ShahLynn H Gerber
Jul 12, 2003·Pain·M KobanF Birklein
Aug 8, 2006·Trends in Neurosciences·John A WemmieMichael J Welsh
Oct 19, 2016·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Marcus GadauChris Zaslawski
Sep 26, 2006·Scandinavian Journal of Rheumatology. Supplement·Thomas Graven-Nielsen
Jan 10, 2018·Frontiers in Cellular Neuroscience·Luis F QuemeMichael P Jankowski
Sep 14, 2004·Journal of Neurobiology·Stephen B McMahon, Nicholas G Jones
Sep 18, 2015·PloS One·Nicholas S GregoryKathleen A Sluka
Oct 17, 2008·The EMBO Journal·Emmanuel DevalEric Lingueglia
May 17, 2003·Journal of Neurophysiology·Darryl T Hamamoto, Donald A Simone
Jan 26, 2007·American Journal of Physiology. Cell Physiology·Takeshi SugiuraG F Gebhart
Oct 22, 2011·Expert Review of Neurotherapeutics·Lars Arendt-Nielsen, Hans Christian Hoeck
Jul 18, 2019·European Journal of Pain : EJP·Line Bay SørensenThomas Graven-Nielsen
Mar 4, 2005·The Journal of Pharmacology and Experimental Therapeutics·Rajan Radhakrishnan, Kathleen A Sluka
May 23, 2015·The Cochrane Database of Systematic Reviews·M Soledad CepedaRoman Schumann
Dec 19, 2017·Experimental Brain Research·Toshiyuki AsakiLars Arendt-Nielsen
Jan 23, 2018·The Journal of Pharmacy and Pharmacology·Marian J Pérez-RodríguezVinicio Granados-Soto
Sep 1, 2004·Current Protocols in Pharmacology·Rajan RadhakrishnanLois J Kehl
Oct 31, 2019·Scientific Reports·Sofia Louca JoungerNikolaos Christidis
Feb 8, 2002·Acta Odontologica Scandinavica·B Hedenberg-MagnussonS Kopp
Jun 9, 2020·Frontiers in Cellular Neuroscience·Melina Papalampropoulou-TsiridouFeng Wang
Jul 19, 2001·Annals of the New York Academy of Sciences·C J Benson, S P Sutherland
Nov 6, 2001·Journal of the National Cancer Institute. Monographs·C Miaskowski
May 8, 2004·Chronobiology International·H J Koch, C Raschka
Jan 23, 2016·American Journal of Physiology. Cell Physiology·Sonia Martial
Nov 4, 2015·Physiology·Ramy E Abdelhamid, Kathleen A Sluka
Oct 4, 2017·World Journal of Gastroenterology : WJG·Michele HummelGarth T Whiteside
Nov 30, 2018·Journal of Biomedical Science·Jiann-Her LinChih-Cheng Chen
Dec 13, 2017·Scandinavian Journal of Pain·Kelun WangLars Arendt-Nielsen
Dec 2, 2020·Channels·Jasdip Singh DulaiTaufiq Rahman
Sep 25, 2007·The Journal of Biological Chemistry·Zoltan GerevichPeter Illes

Related Concepts

Metabolic Acidosis
Hydrogen-Ion Concentration

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.