Pain during venous cannulation: Double-blind, randomized clinical trial of analgesic effect between topical amethocaine and eutectic mixture of local anesthetic.

Journal of Anaesthesiology, Clinical Pharmacology
Cn Yeoh, Cy Lee

Abstract

Venous cannulation is often a painful procedure for the patient. Eutectic mixture of local anesthetic (EMLA) is the commonest topical analgesic used but suffers from disadvantages such as slow onset and skin blanching, which may interfere with venous cannulation. Amethocaine is a newer topical analgesic which seems to be devoid of such problems. This prospective randomized double-blind study compared the analgesic efficacy of EMLA with amethocaine during venous cannulation in adults. Eighty ASA I-II patients, aged 18-65 years, were recruited. The test drug was applied on the designated site of venous cannulation and covered with an occlusive dressing for at least 60 min prior to the procedure. Data collected included visual analogue score (VAS) during first attempt at venous cannulation, the ease and success rate at cannulation, and cutaneous changes at the application site. Mean and median VAS for the EMLA group were 27.9 ± 9.8 and 30 mm, respectively; while for the Amethocaine group were 19.1 ± 14.1 and 20 mm, respectively. Differences in VAS did not reach statistical significance. No statistically significant differences were observed in the ease and success rate at cannulation. Cutaneous changes in the form of local indurat...Continue Reading

Citations

Jun 30, 2015·International Journal of Nursing Studies·Jessica S BahorskiGlenna Gordon
Dec 17, 2014·Revista brasileira de anestesiologia·Volkan HanciSerhan Yurtlu
Oct 28, 2014·British Journal of Nursing : BJN·Donna McGowan
Mar 14, 2021·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Nurten Alan, Leyla Khorshid

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