Pain Experience is Somatotopically Organized and Overlaps with Pain Anticipation in the Human Cerebellum

The Cerebellum
F H S Michelle WelmanJan C Holstege

Abstract

Many fMRI studies have shown activity in the cerebellum after peripheral nociceptive stimulation. We investigated whether the areas in the cerebellum that were activated after nociceptive thumb stimulation were separate from those after nociceptive toe stimulation. In an additional experiment, we investigated the same for the anticipation of a nociceptive stimulation on the thumb or toe. For his purpose, we used fMRI after an electrical stimulation of the thumb and toe in 19 adult healthy volunteers. Following nociceptive stimulation, different areas were activated by stimulation on the thumb (lobule VI ipsilaterally and Crus II mainly contralaterally) and toe (lobules VIII-IX and IV-V bilaterally and lobule VI contralaterally), i.e., were somatotopically organized. Cerebellar areas innervated non-somatotopically by both toe and thumb stimulation were the posterior vermis and Crus I, bilaterally. In the anticipation experiment, similar results were found. However, here, the somatotopically activated areas were relatively small for thumb and negligible for toe stimulation, while the largest area was innervated non-somatotopically and consisted mainly of Crus I and lobule VI bilaterally. These findings indicate that nociceptive s...Continue Reading

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Citations

Jan 9, 2020·The International Journal of Clinical and Experimental Hypnosis·Edoardo CasigliaAnnalena Venneri
Jun 9, 2020·The International Journal of Clinical and Experimental Hypnosis·Seyedeh-Parisa ZareiAli Motie Nasrabadi
Jul 8, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Mohammed S BermoDavid H Lewis
Jul 10, 2020·The Journal of Spinal Cord Medicine·Elizabeth J RichardsonJ Scott Richards
Nov 10, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Anna WoodburyBruce Crosson

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Software Mentioned

SPM
SUIT
AAL
AAL ( Automated Anatomical Labeling )
MATLAB

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