Pain in methadone patients: Time to address undertreatment and suicide risk (ANRS-Methaville trial)

PloS One
Sandra NordmannANRS Methaville study group

Abstract

Pain in opioid-dependent patients is common but data measuring the course of pain (and its correlates) using validated scales in patients initiating methadone treatment are sparse. We aimed to assess pain and its interference in daily life, associated correlates, and undertreatment before and during methadone treatment. This is a secondary analysis using longitudinal data of a randomized trial comparing two methadone initiation models. We assessed the effect of methadone initiation and other correlates on pain intensity and interference (using the Brief Pain Inventory) at months 0, 6 and 12 using a mixed multinomial logistic regression model. The study group comprised 168 patients who had data for either pain intensity or interference for at least one visit. Moderate to severe pain was reported in 12.9% of patients at M0, 5.4% at M6 and 7.3% at M12. Substantial interference with daily functioning was reported in 36.0% at M0, 14.5% at M6 and 17.1% at M12. Of the 98 visits where patients reported moderate to severe pain or substantial interference, 55.1% reported no treatment for pain relief, non-opioid analgesics were reported by 34.7%, opioid analgesics by 3.1% and both opioid and non-opioid analgesics by 7.1%. Methadone was as...Continue Reading

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Aug 8, 2018·Frontiers in Psychiatry·Jessica DelormeNicolas Authier
Mar 20, 2021·The American Journal on Addictions·Zill-E Huma LatifLars Tanum
Jun 24, 2018·The Medical Clinics of North America·Ajay Manhapra, William C Becker

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