Pain inhibitory mechanisms and response to weak analgesics in patients with knee osteoarthritis

European Journal of Pain : EJP
Kristian Kjaer PetersenLars Arendt-Nielsen

Abstract

Conditioned pain modulation (CPM) and offset analgesia are different features of descending pain inhibition. This study investigated CPM, offset analgesia and clinical pain measures in patients with knee osteoarthritis (KOA) before and after treatment with the combination of a non-steroidal anti-inflammatory drug (NSAIDs) plus acetaminophen. Forty-two patients with KOA received Ibuprofen 1.2 g/daily and acetaminophen 3.0 g/daily for three weeks. Before administration, CPM magnitude was assessed as the difference between cuff pain detection (cPDT) with and without a conditioning stimulus (evoked by tourniquet pain). Offset analgesia was assessed as the pain intensities evoked by a constant 46°C for 30-s stimulus compared to an offset analgesia paradigm of 46°C for 5-s, 47°C for 5-s and 46°C for 20-s. The worst pain within the last 24-hr and pain during activity were assessed before and after treatment. Clinical pain significantly decreased after treatment (p < 0.001) and less efficient CPM before treatment was associated with weaker analgesic effect (R = 0.354, p = 0.043). No significant modulation of CPM or offset analgesia was found for the treatment. This study found that less efficient CPM is associated with reduced analgesi...Continue Reading

References

Apr 4, 2002·Journal of Neurophysiology·Joshua D Grill, Robert C Coghill
Jun 13, 2003·Health and Quality of Life Outcomes·Ewa M Roos, Sören Toksvig-Larsen
Dec 3, 2003·Annals of the Rheumatic Diseases·K M JordanUNKNOWN Standing Committee for International Clinical Studies Including Therapeutic Trials ESCISIT
Feb 19, 2005·The Journal of Clinical Investigation·Heiko ReinoldHanns Ulrich Zeilhofer
Mar 17, 2010·European Journal of Pain : EJP·David YarnitskyOliver Wilder-Smith
May 28, 2010·Journal of Pain & Palliative Care Pharmacotherapy·Oliver Hamilton Wilder-SmithLars Arendt-Nielsen
Jul 29, 2010·Nature Reviews. Rheumatology·Thomas Graven-Nielsen, Lars Arendt-Nielsen
Jan 18, 2011·Pain·Marieke NiestersElise Y Sarton
May 10, 2013·European Journal of Pain : EJP·K GrosenA M Drewes
Sep 21, 2013·Nature Reviews. Rheumatology·Anne-Marie Malfait, Thomas J Schnitzer
Sep 16, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Erica SuzanElon Eisenberg
Nov 12, 2015·Physiology & Behavior·Hadas Nahman-AverbuchGiris Jacob
Nov 20, 2016·European Journal of Pain : EJP·T Graven-NielsenL Arendt-Nielsen
Sep 13, 2017·European Journal of Pain : EJP·D LigatoL Arendt-Nielsen
Oct 11, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Maaike Van Den HouteOmer Van den Bergh
Nov 7, 2017·European Journal of Pain : EJP·L Arendt-NielsenA Mohr Drewes

❮ Previous
Next ❯

Citations

Sep 14, 2019·Journal of Neural Transmission·Stevie Lockwood, Anthony H Dickenson
Dec 27, 2019·European Journal of Pain : EJP·Marie Hoeger BementThomas Graven-Nielsen
Jan 8, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Dennis Boye LarsenKristian Kjær Petersen
Oct 23, 2020·Pain·Tonia L Vincent
Feb 4, 2021·European Journal of Pain : EJP·Tibor M SzikszayKerstin Luedtke
May 15, 2021·European Journal of Pain : EJP·Thorvaldur S PalssonThomas Graven-Nielsen
Apr 28, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Kristian Damgaard LyngKristian Kjær Petersen
Oct 14, 2021·Scandinavian Journal of Pain·Dennis Boye LarsenKristian Kjær Petersen
Sep 29, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jonathan RankinLisa C Carlesso

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.