Pain inhibits pain; human brainstem mechanisms

NeuroImage
Andrew M YoussefLuke A Henderson

Abstract

Conditioned pain modulation is a powerful analgesic mechanism, occurring when a painful stimulus is inhibited by a second painful stimulus delivered at a different body location. Reduced conditioned pain modulation capacity is associated with the development of some chronic pain conditions and the effectiveness of some analgesic medications. Human lesion studies show that the circuitry responsible for conditioned pain modulation lies within the caudal brainstem, although the precise nuclei in humans remain unknown. We employed brain imaging to determine brainstem sites responsible for conditioned pain modulation in 54 healthy individuals. In all subjects, 8 noxious heat stimuli (test stimuli) were applied to the right side of the mouth and brain activity measured using functional magnetic resonance imaging. This paradigm was then repeated. However, following the fourth noxious stimulus, a separate noxious stimulus, consisting of an intramuscular injection of hypertonic saline into the leg, was delivered (conditioning stimulus). During this test and conditioning stimulus period, 23 subjects displayed conditioned pain modulation analgesia whereas 31 subjects did not. An individual's analgesic ability was not influenced by gender,...Continue Reading

References

Jul 3, 1990·European Journal of Pharmacology·J C WillerT De Broucker
Oct 2, 1995·The Journal of Comparative Neurology·X F Huang, G Paxinos
Feb 22, 2002·Experimental Physiology·Caroline Gauriau, Jean-François Bernard
Nov 22, 2007·Experimental Brain Research·Irit Weissman-FogelDorit Pud
Apr 5, 2011·Journal of Pain and Symptom Management·Hadas Nahman-AverbuchDorit Pud

❮ Previous
Next ❯

Citations

Oct 27, 2016·Neuroscience·Meritxell Llorca-TorralbaEsther Berrocoso
Jul 9, 2016·Nature Reviews. Neurology·Arne May, Laura H Schulte
Sep 23, 2016·Headache·Laura H Schulte, Arne May
Feb 2, 2017·European Journal of Pain : EJP·N KumowskiE Enax-Krumova
Sep 27, 2016·Medicine and Science in Sports and Exercise·Nirit GevaRuth Defrin
Apr 26, 2017·Cephalalgia : an International Journal of Headache·Juliana Geremias ChichorroBarry Sessle
Apr 28, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Luke A Henderson, Kevin A Keay
Apr 8, 2017·The Journal of Physiology·Kirsty Bannister, A H Dickenson
Jun 3, 2017·European Journal of Pain : EJP·D E Harper, M Hollins
Oct 11, 2017·Cephalalgia : an International Journal of Headache·Dan LevyRuth Defrin
Apr 20, 2018·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·George Shengxi ZhangYi Min Xie
Aug 23, 2019·Brain Structure & Function·Eva MattRoland Beisteiner
Sep 14, 2019·Journal of Neural Transmission·Stevie Lockwood, Anthony H Dickenson
Jan 25, 2018·Somatosensory & Motor Research·Amalie Højmose SimoniParisa Gazerani
Mar 7, 2019·Cephalalgia : an International Journal of Headache·Fleur LereboursNelly Fabre
Oct 4, 2019·Pain Reports·Vitaly NapadowLuke A Henderson
Nov 7, 2019·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Caterina Leone, Andrea Truini
Sep 19, 2020·Journal of Pain Research·Emily P MillsLuke A Henderson
Apr 23, 2016·Human Brain Mapping·Andrew M YoussefLuke A Henderson
Sep 28, 2017·Cephalalgia : an International Journal of Headache·Kasia K MarciszewskiLuke A Henderson
Oct 6, 2020·Neurorehabilitation and Neural Repair·Martin GagnéCatherine Mercier
Nov 11, 2020·European Journal of Pain : EJP·Giovanna SquintaniMichele Tinazzi
Sep 9, 2020·The Journal of Pain : Official Journal of the American Pain Society·Emily P MillsLuke A Henderson
Jan 24, 2018·The Journal of Pain : Official Journal of the American Pain Society·Daniel E HarperSteven E Harte
Jun 16, 2021·Nature Reviews. Neuroscience·Linette Liqi Tan, Rohini Kuner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.