Pain management for sickle cell disease

The Cochrane Database of Systematic Reviews
R J Dunlop, K C L B Bennett

Abstract

Sickle cell disease is an inherited genetic disorder characterized by an abnormality of haemoglobin that predisposes to polymerization and consequent deformation ("sickling"). Sickle cell disease can cause episodes of acute severe pain. Chronic pain may also occur. Currently, pain is inadequately managed. The primary aim of the review was to assess the effectiveness of pharmacological analgesic interventions for pain management in sickle cell disease, including the treatment of acute and chronic pain in children and adults. A pre-defined search strategy was used to electronically search the MEDLINE and EMBASE databases. Searches were also conducted on the Cochrane Controlled Trial Register (CCTR) and the Oxford pain randomised controlled trials citation database. The search period covered from January 1965 through to June 2002. Bibliographies of retrieved studies were searched for additional references. No language restriction was used. All randomised controlled trials involving pharmacological treatment of acute or chronic pain in children or adults with sickle cell disease were selected. Patients with haemoglobin SS, haemoglobin S ss thalassaemia and the haemoglobin SC group were included. Trials were quality rated using the ...Continue Reading

Citations

Apr 26, 2013·Journal of Palliative Medicine·Caterina P MinnitiHunter Groninger
Dec 23, 2015·Clinical Journal of Oncology Nursing·Nadine Matthie, Coretta Jenerette
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Arturo J Martí-CarvajalArturo J Martí-Peña
Oct 23, 2012·British Journal of Pharmacology·Bruno Georg Oertel, Jörn Lötsch
Jan 21, 2014·Pediatric Blood & Cancer·Oluwakemi Badaki-MakunUNKNOWN Pediatric Emergency Care Applied Research Network (PECARN) Magnesium in Sickle Cell Crisis (MAGiC) Study Group
Jun 11, 2011·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Wally R SmithKathryn L Hassell
May 20, 2020·Health Psychology Open·Nadine MatthieLakshmanan Krishnamurti
May 26, 2018·Scandinavian Journal of Pain·Felix Anthony LubegaTonny S Luggya
Feb 2, 2021·Saudi Journal of Medicine & Medical Sciences·Mohammed S Alshahrani, Mohannad A Alghamdi
Aug 24, 2021·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Claire ArbitreEvelyne D Trottier
Aug 23, 2011·Journal of Pain and Symptom Management·Clifton G MealsRebecca P Ramirez

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