PMID: 22352683Feb 23, 2012Paper

Pain management in hematological patients with major organ dysfunctions and comorbid illnesses

Cardiovascular & Hematological Agents in Medicinal Chemistry
Pasquale NiscolaPaolo de Fabritiis

Abstract

Organ dysfunctions and medical complications, such as renal failure, liver impairment, coagulation disorders, cardiovascular and respiratory illnesses, may hamper an adequate pain management in haematological patients. To summarize current knowledge on pain management in hematological patients presenting major organ dysfunctions and comorbidity. We also attempted to provide recommendations to optimize analgesia and to minimize side effects in the setting of medically compromised and frail haematological patients. A systematic search of the literature, using relevant key words, was conducted in PubMed. Pain in hematological patients is a common symptom and is often multi-factorial. Most pharmacotherapeutic measures, including causal therapies, analgesics and adjuvant agents routinely applied in pain management, may also be used in the setting of clinical frailty and medical comorbidities; however, comprehensive clinical and functional patient's evaluations and a careful consideration of expected benefits and potential adverse events are required.

Citations

Aug 5, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Pasquale NiscolaFabio Efficace
Feb 19, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·J Elander
Jan 14, 2020·Immunological Reviews·Michelle A E BrouwerLeo A B Joosten

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