Pain management strategies for neuropathic pain in Fabry disease--a systematic review

BMC Neurology
Y SchullerM Biegstraaten

Abstract

Neuropathic pain is one of the key features of (classical) Fabry disease (FD). No randomized clinical trials comparing effectiveness of different pain management strategies have been performed. This review aims to give an overview of existing pain management strategies. PubMed and Embase were searched up to September 2014 for relevant articles on treatment of neuropathic pain in FD. Seven-hundred-thirty-one articles were identified of which 26 were included in the analysis. Studies reported on 55 individuals in total, with group-sizes ranging from 1 to 8. Carbamazepine appeared most beneficial: complete pain relief in 5/25, partial relief in 17/25, and no benefit in 3/25 patients. Phenytoin resulted in complete relief in 1/27, partial relief in 12/27 and no benefit in 6/27 patients. In 8 patients a significant reduction in the frequency of pain attacks was described. Gabapentin caused partial relief in 6/7 and no relief in 1/7 patients. Little evidence was reported for SSNRI's or treatment combinations. Adverse-effects were reported in all treatment strategies. Only for carbamazepine, phenytoin and gabapentin there is evidence of effectiveness in neuropathic pain due to FD, but comparison of effectiveness between these drugs is...Continue Reading

References

Jul 1, 1979·Arthritis and Rheumatism·K J Sheth, G C Bernhard
Jun 15, 1977·Acta Neuropathologica·F M ToméG Lenoir
Oct 27, 1975·Acta Neuropathologica·N FukuharaT Tsubaki
Sep 1, 1992·Brain & Development·M InagakiK Takeshita
Dec 1, 1992·Clinical Rheumatology·S O PairaH A Barceló
May 1, 1990·Pediatric Neurology·M InagakiK Takeshita
Jan 1, 1973·Journal of the Neurological Sciences·H ShibasakiY Kuroiwa
Aug 1, 1973·Neurology·L A LockmanR J Desnick
Feb 1, 1968·Archives of Disease in Childhood·A W JohnstonB J Warland
May 25, 1967·The New England Journal of Medicine·R O BradyL Laster
Apr 1, 1995·Pediatric Neurology·K E GordonG A Finley
Dec 30, 1993·Biochemical and Biophysical Research Communications·S IshiiY Suzuki
Jul 15, 1996·Hospital Practice·R Hariharan, H L Fred
Mar 9, 1999·American Journal of Medical Genetics·I E KnolB T Poll-The
Dec 6, 2000·JAMA : the Journal of the American Medical Association·R O Brady, R Schiffmann
Mar 27, 2001·Lancet·M M Chowdhury, P J Holt
Apr 17, 2001·The American Journal of Nursing·V L Stryker, C Kreps
Jun 21, 2001·JAMA : the Journal of the American Medical Association·R SchiffmannR O Brady
Jun 26, 2001·The British Journal of Dermatology·M M Chowdhury, P J Holt
Jul 7, 2001·The New England Journal of Medicine·C M EngUNKNOWN International Collaborative Fabry Disease Study Group
Nov 8, 2001·European Journal of Pharmacology·J MacDermot, K D MacDermot
Apr 16, 2002·Epilepsia·Philip N PatsalosClementina M van Rijn
Jun 28, 2002·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·K F GoldC L Pashos
Sep 25, 2002·Psychosomatic Medicine·Jeffrey DershRobert J Gatchel
Oct 29, 2002·Muscle & Nerve·Carlos A LucianoRaphael Schiffmann
Dec 19, 2002·Internal Medicine·Koichi AsahiTsuyoshi Watanabe
Jan 7, 2003·Internal Medicine Journal·J GalanosG Becker
Feb 8, 2003·Acta Paediatrica. Supplement·R Schiffmann, L J C Scott
Sep 16, 2003·Journal of Inherited Metabolic Disease·M RiesM Beck
Sep 25, 2003·European Journal of Pediatrics·Markus RiesMichael Beck
Mar 18, 2004·European Journal of Clinical Investigation·A MehtaM Beck
Mar 19, 2004·QJM : Monthly Journal of the Association of Physicians·A Chaudhuri
Apr 16, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Leyla TümerAyşe Dursun
May 26, 2004·Lancet·O A BodamerS Stöckler-Ipsiroglu
Sep 25, 2004·Muscle & Nerve·David LacomisLaurie Mathie
Aug 3, 2005·Pediatric Dermatology·Sourab ChoudhuryHelen T Shin
Jan 25, 2006·Journal of Palliative Medicine·Joel RaskinJ F Wernicke
Feb 21, 2006·British Journal of Clinical Pharmacology·Emilio Perucca
Mar 15, 2006·Archives of Neurology·Christopher S NanceRobert J Desnick
Sep 5, 2006·Pediatrics·Markus RiesRaphael Schiffmann
Aug 21, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Olivier LidoveThomas Papo

❮ Previous
Next ❯

Citations

Feb 23, 2020·Journal of Inherited Metabolic Disease·Sanne J van der VeenMirjam Langeveld
Oct 14, 2016·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·K V Firsov, A S Kotov
Aug 1, 2020·Der Schmerz·D EmmertM Mücke
Oct 6, 2020·Molecular Genetics & Genomic Medicine·Takaaki SawadaKimitoshi Nakamura
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hyun-Yong KimSoon-Sung Lim
Apr 4, 2021·International Journal of Environmental Research and Public Health·Fabio CaputoGiorgio Zoli

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
enzyme replacement therapy
sedation
pharmacotherapy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.