Pain management using photobiomodulation: Mechanisms, location, and repeatability quantified by pain threshold and neural biomarkers in mice

Journal of Biophotonics
Marcelo Victor Pires de SousaMichael R Hamblin

Abstract

Photobiomodulation (PBM) is a simple, efficient and cost-effective treatment for both acute and chronic pain. We previously showed that PBM applied to the mouse head inhibited nociception in the foot. Nevertheless, the optimum parameters, location for irradiation, duration of the effect and the mechanisms of action remain unclear. In the present study, the pain threshold in the right hind paw of mice was studied, after PBM (810 nm CW laser, spot size 1 or 6 cm2 , 1.2-36 J/cm2 ) applied to various anatomical locations. The pain threshold, measured with von Frey filaments, was increased more than 3-fold by PBM to the lower back (dorsal root ganglion, DRG), as well as to other neural structures along the pathway such as the head, neck and ipsilateral (right) paw. On the other hand, application of PBM to the contralateral (left) paw, abdomen and tail had no effect. The optimal effect occurred 2 to 3 hours post-PBM and disappeared by 24 hours. Seven daily irradiations showed no development of tolerance. Type 1 metabotropic glutamate receptors decreased, and prostatic acid phosphatase and tubulin-positive varicosities were increased as shown by immunofluorescence of DRG samples. These findings elucidate the mechanisms of PBM for pain...Continue Reading

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Citations

Feb 12, 2019·Journal of Cellular Physiology·Iuliia GolovynskaTymish Y Ohulchanskyy
Oct 5, 2019·Cellular and Molecular Life Sciences : CMLS·Mariia LunovaOleg Lunov
Nov 30, 2019·Pain Practice : the Official Journal of World Institute of Pain·Glauce R PigattoNivaldo A Parizotto
Oct 14, 2020·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Camilla Garcia OliveiraMarucia Chacur
Feb 27, 2021·The Journal of Pain : Official Journal of the American Pain Society·Kevin ChengMohab M Ibrahim
Apr 13, 2021·Photobiomodulation, Photomedicine, and Laser Surgery·Won Sang YooPhil-Sang Chung

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