PMID: 11605940Oct 19, 2001Paper

Pain models display differential sensitivity to Ca2+-permeable non-NMDA glutamate receptor antagonists

Anesthesiology
L S SorkinC M Doom

Abstract

Ca2+-permeable non-N-methyl-D-aspartate receptors are found in the spinal dorsal horn and represent a presumptive target for glutamatergic transmission in nociceptive processing. This study characterized the analgesic profile associated with the blockade of these spinal receptors by intrathecally delivered agents known to act at these receptors, the spider venom Joro toxin (JST) and philanthotoxin. Philanthotoxin (0.5, 2.5, or 5 microg) or JST (5 microg) was given spinally before thermal injury to the paw. JST (5 microg) was also given 10 min before subcutaneous formalin injection, after intraplantar administration of carrageenan, and to rats that were allodynic due to tight ligation of spinal nerves. Lower doses of JST (0.25 and 1.0 microg) were given before formalin injection and testing of thermal latencies. Thermal latencies were measured using a Hargreaves box, mechanical thresholds using von Frey hairs, and formalin response by means of counting flinches. Both agents blocked thermal injury-induced mechanical allodynia. JST (5 microg) given 1 h after carrageenan blocked induction of thermal hyperalgesia and mechanical allodynia. JST (5 microg) had no effect in the formalin test, on allodynia after spinal nerve ligation, or...Continue Reading

References

Aug 3, 1990·Science·K KeinänenP H Seeburg
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·S D Donevan, M A Rogawski
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Aug 1, 1997·The Journal of Biological Chemistry·J D English, J D Sweatt
Jan 14, 1998·Neuron·J Lerma
Oct 21, 1998·Neuroscience Letters·N Nozaki-Taguchi, T L Yaksh
Aug 24, 1999·The European Journal of Neuroscience·C AlbuquerqueA B MacDermott
May 18, 2001·Journal of Applied Physiology·T L YakshM C Yaksh
Dec 1, 1976·Physiology & Behavior·T L Yaksh, T A Rudy

❮ Previous
Next ❯

Citations

Oct 31, 2009·Molecular Neurobiology·Max Larsson
Oct 11, 2003·Molecular and Cellular Neurosciences·Emer M GarrySusan M Fleetwood-Walker
Nov 26, 2008·Annales Françaises D'anesthèsie Et De Rèanimation·M CrousierV Piriou
Oct 16, 2008·Journal of Neuroscience Research·Linda SorkinW Marie Campana
Jul 16, 2010·The European Journal of Neuroscience·Xue Jun Liu, Michael W Salter
Oct 15, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B BanerjeeR Shaker
Oct 7, 2004·Brain Research. Brain Research Reviews·Emer M GarrySusan M Fleetwood-Walker
Jul 1, 2004·Toxicon : Official Journal of the International Society on Toxinology·Wudayagiri RajendraKandiah Jeyaseelan
Aug 24, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·P RichebéG Simonnet
Feb 3, 2007·Natural Product Reports·Georgina EstradaGerardo Corzo
Aug 27, 2017·Journal of Molecular Neuroscience : MN·Baixue WuLixue Chen
Oct 6, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Veronika KharivStella Elkabes
Nov 10, 2011·Toxins·Adak NasiripourdoriAntoine Taly
Apr 2, 2010·Journal of Medicinal Chemistry·Henri MattesManuel Koller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.