Pain Modulation: From Conditioned Pain Modulation to Placebo and Nocebo Effects in Experimental and Clinical Pain

International Review of Neurobiology
Janie DamienSerge Marchand

Abstract

Accumulating evidence reveal important applications of endogenous pain modulation assessment in healthy controls and in patients in clinical settings, as dysregulations in the balance of pain modulatory circuits may facilitate pain and promote chronification of pain. This article reviews data on pain modulation, focusing on the mechanisms and translational aspects of pain modulation from conditioned pain modulation (CPM) to placebo and nocebo effects in experimental and clinical pain. The specific roles of expectations, learning, neural and neurophysiological mechanisms of the central nervous system are briefly reviewed herein. The interaction between CPM and placebo systems in pain inhibitory pathways is highly relevant in the clinic and in randomized controlled trials yet remains to be clarified. Examples of clinical implications of CPM and its relationship to placebo and nocebo effects are provided. A greater understanding of the role of pain modulation in various pain states can help characterize the manifestation and development of chronic pain and assist in predicting the response to pain-relieving treatments. Placebo and nocebo effects, intrinsic to every treatment, can be used to develop personalized therapeutic approac...Continue Reading

Associated Clinical Trials

Citations

Mar 5, 2019·Current Rheumatology Reports·QiLiang Chen, Mary M Heinricher
Jul 26, 2019·European Journal of Pain : EJP·Morten HoeghThomas Graven-Nielsen
Sep 19, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Esther FlorinSusanne Becker
Oct 29, 2020·Biology of Sex Differences·Hugo M PereiraAndré F Kohn
Nov 3, 2020·Frontiers in Physiology·Beverly TanToby Mündel
Feb 23, 2021·Cephalalgia : an International Journal of Headache·Caroline M KopruszinskiFrank Porreca
Mar 31, 2021·Rheumatic Diseases Clinics of North America·Priyanka Iyer, Yvonne C Lee
Apr 7, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Guillermo García-BarajasJulian Taylor
Jun 10, 2021·Pain Reports·Greig AdamsTim V Salomons
Jul 9, 2021·Current Rheumatology Reports·Felipe C K DuarteDinesh A Kumbhare
Aug 19, 2021·Cephalalgia : an International Journal of Headache·Julia JessenElena K Enax-Krumova
Sep 11, 2021·The Journal of Physiology·Altamash S HassanGregory E P Pearcey
Oct 20, 2020·Psychotherapy and Psychosomatics·Andrea W M EversUNKNOWN Consortium of Placebo Experts
Nov 18, 2021·Cephalalgia : an International Journal of Headache·Jan Petter NeverdahlPetter Moe Omland

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