Pain-motor integration in the primary motor cortex in Parkinson's disease

Brain Stimulation
A SuppaAlfredo Berardelli

Abstract

In Parkinson's disease (PD), the influence of chronic pain on motor features has never been investigated. We have recently designed a technique that combines nociceptive system activation by laser stimuli and primary motor cortex (M1) activation through transcranial magnetic stimulation (TMS), in a laser-paired associative stimulation design (Laser-PAS). In controls, Laser-PAS induces long-term changes in motor evoked potentials reflecting M1 long-term potentiation-like plasticity, arising from pain-motor integration. We here examined the possible influence of chronic pain on motor responses to Laser-PAS in patients with PD, with and without chronic pain. We compared motor responses to Laser-PAS in healthy subjects and in patients with PD, with and without chronic pain. Unlike controls, we found reduced responses to Laser-PAS in patients with PD, with and without pain. Patients off and on dopaminergic therapy had similar responses to Laser-PAS. When comparing responses to Laser-PAS in patients with and without pain, the two patients' subgroups had similar abnormalities. When we compared patients with pain in the body region investigated with Laser-PAS, with those with pain in other body regions, we found prominent changes in pa...Continue Reading

Citations

Nov 28, 2019·Clinical Parkinsonism & Related Disorders·Yi-Cheng Tai, Chin-Hsien Lin
Jul 25, 2021·Behavioural Brain Research·Giacomo GuidaliNadia Bolognini
Sep 3, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·G Cruccu, A Suppa

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