PMID: 3763235Aug 1, 1986Paper

Pain perception decrement produced through repeated stimulation

Pain
M ErnstH H Zaretsky

Abstract

Pain responses (pain detection and pain discomfort) to electrical dental stimulation were studied in 16 normal subjects. The repetition of the dental stimuli induced a significant and long-lasting (60 min) decrease in pain sensitivity at both sensory levels (after 60 min of repetitive stimulation, 79% increase in pain detection, P less than 0.0001, 45% increase in pain discomfort, P less than 0.0004). The sensory response decrement through repeated elicitation was not influenced by naloxone administration (1.2 mg i.m.). This study clearly demonstrates the induction of pain sensory decrease through repetitive stimulation which differs from peripheral sensory receptor adaptation, from the inhibitory gating mechanism or from diffuse inhibitory controls activation; its unresponsiveness to naloxone suggests that this phenomenon is not opioid-dependent. A technique has been standardized which will enable the systematic study of pain decrease under sustained nociceptive stimulation in chronic pain patients.

References

Jun 1, 1978·Journal of Molecular and Cellular Cardiology·P A Poole-Wilson
Apr 27, 1978·Nature·J D LevineH L Fields
Feb 19, 1979·Life Sciences·M SatohH Takagi
Feb 1, 1975·Behavioral Biology·J A Deutsch, S G Dennis
May 1, 1973·Postgraduate Medicine·J J Bonica
Jun 1, 1974·Journal of Neurology, Neurosurgery, and Psychiatry·H E Torebjörk, R G Hallin
Apr 1, 1972·Journal of Neurology, Neurosurgery, and Psychiatry·M R DimitrijevićJ K Trontelj
Nov 1, 1965·Archives of Oral Biology·J M Mumford
Nov 19, 1965·Science·R Melzack, P D Wall
Jan 1, 1966·Psychological Review·R F Thompson, W A Spencer
Apr 1, 1967·Psychophysiology·B Tursky, D J Greenblatt
Oct 1, 1956·Journal of Dental Research·F VARGAS
Apr 1, 1965·The Journal of Physiology·W R LOEWENSTEIN, M MENDELSON

❮ Previous
Next ❯

Citations

Jan 1, 1991·Journal of Psychosomatic Research·M L Peters, A J Schmidt
Nov 5, 2002·European Journal of Pain : EJP·Romanas PolianskisLars Arendt-Nielsen
Jan 1, 1997·European Journal of Pain : EJP·R J LaursenL Arendt-Nielsen
Oct 16, 2002·Brain Research. Brain Research Protocols·Katsunori MotohashiYoshiko Fujii
Sep 18, 2001·European Journal of Pain : EJP·R PolianskisL Arendt-Nielsen
Sep 26, 1997·The Clinical Journal of Pain·S Lautenbacher, G B Rollman
Apr 29, 2014·The Journal of Pain : Official Journal of the American Pain Society·Marieke JepmaTor D Wager
May 20, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Claire E WilcoxPaul G Mullins
Oct 17, 2009·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·A MobascherG Winterer
Jan 10, 2016·Social Cognitive and Affective Neuroscience·William P HoranMichael F Green
Feb 19, 2008·European Journal of Pain : EJP·Ruth DefrinKaren D Davis
Mar 7, 2012·European Journal of Pain : EJP·Y BabaL Arendt-Nielsen
Mar 13, 2012·European Journal of Pain : EJP·M BreimhorstF Birklein
Mar 17, 2012·Pain·Daniel E Harper, Mark Hollins
Nov 19, 2002·Pain·Romanas PolianskisLars Arendt-Nielsen
Nov 1, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Dieter KleinböhlRupert Hölzl
Mar 17, 2017·The Journal of Pain : Official Journal of the American Pain Society·Stella IacovidesFiona C Baker
Sep 26, 2006·Scandinavian Journal of Rheumatology. Supplement·T Graven-Nielsen
Jun 30, 2018·European Journal of Pain : EJP·M HoeghT Graven-Nielsen
Oct 1, 1989·Perceptual and Motor Skills·S LautenbacherF Strian
Sep 25, 2018·Frontiers in Psychology·Chenbo Wang, Jing Tian
Feb 28, 2021·The Journal of Physiology·Alessio GallinaJean-Sébastien Blouin
Aug 16, 2021·Applied Ergonomics·Parth Shah, Yan Luximon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.