Pain, Quality of Life, and Safety Outcomes of Kyphoplasty for Vertebral Compression Fractures: Report of a Task Force of the American Society for Bone and Mineral Research

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Alexander J RodriguezPeter R Ebeling

Abstract

The relative efficacy and harms of balloon kyphoplasty (BK) for treating vertebral compression fractures (VCF) are uncertain. We searched multiple electronic databases to March 2016 for randomized and quasi-randomized controlled trials comparing BK with control treatment (nonsurgical management [NSM], percutaneous vertebroplasty [PV], KIVA VCF treatment system [Benvenue Medical, Inc., Santa Clara, CA, USA], vertebral body stenting, or other) in adults with VCF. Outcomes included back pain, back disability, quality of life, new VCF, and adverse events (AEs). One reviewer extracted data, a second checked accuracy, and two rated risk of bias (ROB). Mean differences and 95% confidence intervals (CIs) were calculated using inverse-variance models. Risk ratios of new VCF and AE were calculated using Mantel-Haenszel models. Ten unique trials enrolled 1837 participants (age range, 61 to 76 years; 74% female), all rated as having high or uncertain ROB. Versus NSM, BK was associated with greater reductions in pain, back-related disability, and better quality of life (k = 1 trial) that appeared to lessen over time, but were less than minimally clinically important differences. Risk of new VCF at 3 and 12 months was not significantly diffe...Continue Reading

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Citations

Jan 25, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Peter R EbelingMary L Bouxsein
Jan 25, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bart L Clarke, Sundeep Khosla
May 29, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Peter R EbelingMary L Bouxsein
Jan 29, 2020·Der Radiologe·Sönke Langner, Christian Henker
Jun 9, 2020·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Yao LiXiangyang Wang
Jun 3, 2020·Scientific Reports·Matthias PumbergerYannick Palmowski
Jul 28, 2020·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Koji MatsumotoYasuaki Tokuhashi

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