Pain-Related Behavior and Brain Activation in a Cynomolgus Macaque Model of Postoperative Pain

CNS & Neurological Disorders Drug Targets
Aldric T HamaH Takamatsu

Abstract

Inadequate postoperative pain management could lead to persistent pain and this is, in part, due to incomplete understanding of the mechanism of postoperative pain. Currently available rodent models may have limited translatability to clinical postoperative pain. Thus, a preclinical model of postoperative pain was developed in the cynomolgus macaque, a species that is phylogenetically closer to humans than rodents. The presence of pressure hypersensitivity was assessed with non-noxious pressure applied proximally and distally (approximately 10 cm) to an abdominal incision in macaques. The effect of the opioid morphine (intramuscular, i.m.), the nonsteroidal anti-inflammatory drug diclofenac (i.m.) and the anticonvulsant pregabalin (i.m.) on pressure hypersensitivity was evaluated one and two days following surgery. Brain activation during non-noxious pressure stimulation was observed with functional magnetic resonance imaging. Hypersensitivity to non-noxious pressure applied proximally and distally (approximately 10 cm) to the incision was observed, lasting for up to seven days and three days, respectively, following surgery. Postoperative pressure hypersensitivity was attenuated with morphine but not with either diclofenac or ...Continue Reading

Citations

Oct 4, 2019·Pain Reports·Joyce T Da Silva, David A Seminowicz
Nov 27, 2019·Spine Surgery and Related Research·Hiroki UshirozakoYukihiro Matsuyama
May 19, 2020·CNS & Neurological Disorders Drug Targets·Chryssa PourzitakiVasilios K Kimiskidis
Jun 24, 2020·Peptides·Richard J Bodnar

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