Pain-Relieving Effects of mTOR Inhibitor in the Anterior Cingulate Cortex of Neuropathic Rats

Molecular Neurobiology
Sun Woo UmBae Hwan Lee

Abstract

The anterior cingulate cortex (ACC) is a well-known brain area that is associated with pain perception. Previous studies reported that the ACC has a specific role in the emotional processing of pain. Chronic pain is characterized by long-term potentiation that is induced in pain pathways and contributes to hyperalgesia caused by peripheral nerve injury. The mammalian target of rapamycin (mTOR) signaling, which is involved in synaptic protein synthesis, could be a key factor controlling long-term potentiation in neuropathic pain conditions. Until now, there have been no reports that studied the role of mTOR signaling in the ACC involved in neuropathic pain. Therefore, this study was conducted to determine the relationship of mTOR signaling in the ACC and neuropathic pain. Male Sprague-Dawley rats were subjected to cannula implantation and nerve injury under pentobarbital anesthesia. Microinjection with rapamycin into the ACC was conducted under isoflurane anesthesia on postoperative day (POD) 7. A behavioral test was performed to evaluate mechanical allodynia, and optical imaging was conducted to observe the neuronal responses of the ACC to peripheral stimulation. Inhibition of mTOR by rapamycin reduced mechanical allodynia, dow...Continue Reading

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Citations

May 18, 2020·International Journal of Molecular Sciences·Kai K KummerMichaela Kress
Oct 18, 2019·International Journal of Molecular Sciences·Qun LiC David Mintz
Nov 19, 2020·Pharmacological Reviews·Muhammad Saad YousufTheodore J Price
May 1, 2020·Trends in Neurosciences·Sabrina van HeukelumMartha N Havenith
Apr 4, 2021·International Journal of Molecular Sciences·Do Hyeong GwonSun Yeul Lee
Apr 17, 2021·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jing-Hui FengHong-Won Suh
Jun 3, 2021·Biomedicines·Myeong Seong BakSun Kwang Kim
May 31, 2021·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Igor Rafael Correia Rocha, Marucia Chacur

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Methods Mentioned

BETA
amputation

Software Mentioned

ImageJ
SPSS
BV Analyzer
gage
Multi

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