Pain sensitization in people with knee osteoarthritis: a systematic review and meta-analysis

Osteoarthritis and Cartilage
C FingletonC Doody

Abstract

Emerging evidence suggests that pain sensitization plays an important role in pain associated with knee osteoarthritis (OA). This systematic review and meta-analysis examined the evidence for pain sensitization in people with knee OA and the relationship between pain sensitization and symptom severity. A search of electronic databases and reference lists was carried out. All full text observational studies published between 2000 and 2014 with the aim of investigating pain sensitization in humans with knee OA using quantitative sensory testing (QST) measures of hyperalgesia and central hyperexcitability were eligible for inclusion. Meta-analysis of data was carried out using a random effects model, which included results comparing knee OA participants to controls, and results comparing high symptom severity to low symptom severity. Fifteen studies were identified following screening and quality appraisal. For the meta-analysis, pressure pain threshold (PPT) and heat pain threshold (HPT) means and standard deviations were pooled using random effects models. The point estimate was large for differences in PPTs between knee OA participants and controls [-0.85; confidence interval (CI): -1.1 to -0.6], and moderate for PPT difference...Continue Reading

References

May 15, 2003·Arthritis and Rheumatism·J A DesmeulesT L Vischer
Feb 8, 2008·The Journal of Bone and Joint Surgery. British Volume·H LundbladK A Jansson
May 30, 2009·Arthritis and Rheumatism·Laura R ThompsonUNKNOWN Osteoarthritis Initiative Investigators
Jul 25, 2009·The Journal of Pain : Official Journal of the American Pain Society·Carol A CourtneyT George Hornby
Apr 27, 2010·Pain·Lars Arendt-NielsenThomas Graven-Nielsen
Sep 22, 2010·Current Rheumatology Reports·Goran Pavlaković, Frank Petzke
Feb 10, 2011·Nature Reviews. Neurology·Irene Tracey
Mar 29, 2011·Osteoarthritis and Cartilage·J R HochmanG A Hawker
Nov 1, 2011·Seminars in Arthritis and Rheumatism·Mira MeeusJo Nijs
Nov 8, 2011·Journal of Medical Genetics·Erin E YoungInna Belfer
Nov 29, 2011·Rheumatology·Vikki WyldePaul Dieppe
Dec 8, 2011·The Clinical Journal of Pain·Alicia J Emerson KavchakCarol A Courtney
Jul 17, 2012·Current Rheumatology Reports·Hans-Georg Schaible
Sep 18, 2012·The Journal of Pain : Official Journal of the American Pain Society·Gwyn N LewisPeter J McNair
Sep 26, 2012·European Journal of Pain : EJP·J Van OosterwijckL Paul
Oct 12, 2012·Current Pain and Headache Reports·Carol A CourtneyT George Hornby
Apr 3, 2013·Nature Reviews. Rheumatology·Luda DiatchenkoWilliam Maixner
Apr 5, 2014·European Journal of Pain : EJP·E LluchJ Van Oosterwijck

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Citations

Mar 6, 2016·Osteoarthritis and Cartilage·S OgawaH Takamatsu
Sep 22, 2015·The Journal of Orthopaedic and Sports Physical Therapy·Melanie L PlinsingaPaul van Wilgen
Mar 24, 2016·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Henning MadryPeter Angele
Aug 4, 2015·Current Osteoporosis Reports·Rachel E MillerAnne-Marie Malfait
Apr 27, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Marcella Ferraz PazzinattoFábio Mícolis de Azevedo
Jul 19, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Pascale Vergne-Salle
Aug 10, 2016·Annals of the New York Academy of Sciences·Jianlu WeiChuanju Liu
May 7, 2016·Pain·Laura A Frey-LawBarbara A Rakel
Aug 20, 2016·Pain Practice : the Official Journal of World Institute of Pain·Helen O'LearyCatherine M Doody
Jul 12, 2016·Haemophilia : the Official Journal of the World Federation of Hemophilia·S KrügerT Hilberg
Feb 6, 2017·Pain·Lars Arendt-Nielsen
Aug 16, 2016·The Clinical Journal of Pain·Caitríona FingletonCatherine M Doody
May 31, 2017·Pain Practice : the Official Journal of World Institute of Pain·Roy La ToucheDaniel Muñoz-García
Jan 24, 2018·Rheumatology·Rachel E MillerAnne-Marie Malfait
Feb 28, 2018·Physiotherapy Theory and Practice·Debora Bevilaqua-GrossiAnamaria Oliveira
Dec 10, 2017·Disability and Rehabilitation·Wietske RienstraInge van den Akker-Scheek
Jun 24, 2018·European Journal of Pain : EJP·S OdaM Ikeuchi
May 4, 2018·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Nuno MoraisJorge Pereira Machado
Apr 12, 2018·The Clinical Journal of Pain·Stephen J NevilleSteven E Harte
Jan 20, 2018·Pain Practice : the Official Journal of World Institute of Pain·Abdullah Mohammad AlqarniRamakrishnan Mani
Nov 14, 2018·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Danilo De Oliveira SilvaChristian John Barton
Nov 2, 2018·Current Rheumatology Reports·Feng Pan, Graeme Jones
Feb 22, 2018·Der Schmerz·K MillsN Moloney
Oct 17, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kharma C FoucherCarol A Courtney
Feb 14, 2019·The Journal of Orthopaedic and Sports Physical Therapy·Dhinu J JayaseelanHolly Jonely
Jan 15, 2019·Arthritis & Rheumatology·Freija Ter HeegdeChantal Chenu
Jun 29, 2018·Current Rheumatology Reviews·Y V Raghava Neelapala

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