Pain therapeutics from cone snail venoms: From Ziconotide to novel non-opioid pathways

Journal of Proteomics
Helena Safavi-HemamiBaldomero M Olivera

Abstract

There have been numerous attempts to develop non-opioid drugs for severe pain, but the vast majority of these efforts have failed. A notable exception is Ziconotide (Prialt®), approved by the FDA in 2004. In this review, we summarize the present status of Ziconotide as a therapeutic drug and introduce a wider framework: the potential of venom peptides from cone snails as a resource providing a continuous pipeline for the discovery of non-opioid pain therapeutics. An auxiliary theme that we hope to develop is that these venoms, already a validated starting point for non-opioid drug leads, should also provide an opportunity for identifying novel molecular targets for future pain drugs. This review comprises several sections: the first focuses on Ziconotide as a therapeutic (including a historical retrospective and a clinical perspective); followed by sections on other promising Conus venom peptides that are either in clinical or pre-clinical development. We conclude with a discussion on why the outlook for discovery appears exceptionally promising. The combination of new technologies in diverse fields, including the development of novel high-content assays and revolutionary advancements in transcriptomics and proteomics, puts us ...Continue Reading

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Citations

Feb 29, 2020·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Bethany Moos
Jul 28, 2020·Biomedicines·Walden E Bjørn-YoshimotoHelena Safavi-Hemami
Feb 8, 2019·Nature Reviews. Drug Discovery·Heike WulffVladimir Yarov-Yarovoy
Feb 18, 2020·Natural Product Reports·Saumya BajajK George Chandy
May 14, 2020·Pharmacological Reports : PR·Emanuelle Sistherenn CaminskiAlessandra Hubner de Souza
May 24, 2020·Biomedicines·David T WilsonNorelle L Daly
Aug 24, 2020·Bioorganic & Medicinal Chemistry·Fernanda C CardosoPeter J Duggan
Mar 26, 2021·Journal of Natural Products·Gabriel D BosseJoanna Gajewiak
Jun 8, 2021·RSC Medicinal Chemistry·Ashlin TurnerDavid J Craik
Jul 8, 2021·Proceedings. Biological Sciences·Alexander FedosovNicolas Puillandre
Dec 16, 2020·ACS Biomaterials Science & Engineering·Antonio R CerulloAdam B Braunschweig
Jan 29, 2020·Biochemistry·Dharmeshkumar PatelCraig A Doupnik
Sep 3, 2020·Toxicon : Official Journal of the International Society on Toxinology·Alessandra GalloElisabetta Tosti

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