Painful proximal diabetic neuropathy: inflammatory nerve lesions and spontaneous favorable outcome

Annals of Neurology
G SaidG Slama

Abstract

Proximal diabetic neuropathy is a disabling neuropathy that occurs predominantly in non-insulin-dependent diabetic patients over the age of 50. Inflammatory lesions have been found in nerve biopsy specimens of diabetic patients with severe proximal neuropathy or with other patterns of multifocal neuropathy. Some of these patients respond dramatically to treatment with corticosteroids or with other immunomodulators. In this article we report on our findings in 4 additional patients with painful proximal diabetic neuropathy and different patterns of inflammatory nerve lesions whose condition improved spontaneously shortly after performance of a nerve biopsy, without additional treatment.

References

Nov 1, 1991·Archives of Neurology·R J BarohnJ R Mendell
Jan 1, 1986·Acta Neuropathologica·J G LlewelynP Dandona
Jul 4, 1968·The New England Journal of Medicine·M C Raff, A K Asbury
Mar 11, 1972·British Medical Journal·E B Casey, M J Harrison
May 1, 1968·Archives of Neurology·M C RaffA K Asbury
Nov 1, 1995·Archives of Neurology·D A KrendelL C Hopkins
May 1, 1994·Annals of Neurology·G SaidA Moulonguet
Jun 1, 1996·Journal of Neurology·G Said
Nov 1, 1960·Neurology·J R CALVERLEY, D W MULDER

❮ Previous
Next ❯

Citations

May 22, 2001·Muscle & Nerve·J S KatzR J Barohn
Mar 20, 2003·Current Diabetes Reports·Rayaz A Malik
Feb 17, 2001·Current Treatment Options in Neurology·Anthony A. Amato, Richard J. Barohn
Jun 6, 2007·Nature Clinical Practice. Neurology·Gérard Said
Jun 1, 2003·Journal of Clinical Neuromuscular Disease·A Gordon Smith, Mark B Bromberg
Apr 15, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S KurtU Erkorkmaz
Oct 16, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·S S JaradehL J Lobeck
Nov 12, 2013·Neuroimaging Clinics of North America·Tae ChungThomas E Lloyd
May 7, 2013·Neurologic Clinics·Mamatha PasnoorRichard J Barohn
May 7, 2013·Neurologic Clinics·Mamatha PasnoorRichard J Barohn
Mar 3, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Franco Gemignani
Mar 23, 2011·Annals of Neurology·Mercedes Garces-SanchezP James B Dyck
May 27, 2004·Diabetes Care·Andrew J M BoultonJay M Sosenko
Mar 18, 2008·Arquivos de neuro-psiquiatria·Gérard Said
Mar 27, 2004·Pediatric Diabetes·Daniela TrottaFrancesco Chiarelli
Sep 28, 2002·Current Opinion in Neurology·Christian Krarup
Dec 30, 2014·The Journal of the American Academy of Orthopaedic Surgeons·Bennett Douglas GrimmEric B Laxer
Apr 5, 2003·Acta Neurologica Scandinavica·D W ZochodneC Jones
Apr 29, 1999·Brain Pathology·D W Zochodne
Aug 22, 2001·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·V Bril
Oct 8, 1999·Acta Neurologica Scandinavica·H Andersen
Dec 13, 2000·Diabetes/metabolism Research and Reviews·K SugimotoA A Sima
Mar 7, 1998·Neurologic Clinics·G Said

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.