Painful stimulation of a sensitized site in the forearm inhibits ipsilateral trigeminal nociceptive blink reflexes

Experimental Brain Research
P D DrummondL Vo

Abstract

Exposure to moderate levels of ultraviolet B radiation (UVB) is painless but nevertheless induces an inflammatory response that sensitizes primary afferent nociceptors. Subsequently, heating the UVB-treated site can sensitize spinal nociceptors. We used a repeated-measures design to determine whether heating the UVB-treated site also triggers ipsilateral inhibitory controls. Specifically, a 2-cm diameter site on the forearm of 20 participants was exposed to UVB at twice the minimum erythema dose. 48 h later mechanical and thermal sensitivity had increased at the UVB-treated site, indicating primary hyperalgesia. In addition, sensitivity to blunt pressure had increased in the ipsilateral forehead, implying activation of an ipsilateral supra-spinal pro-nociceptive mechanism. Despite this, the area under the curve of the ipsilateral nociceptive blink reflex decreased when the UVB-treated site was heated to induce moderate pain. Together, these findings suggest that the UVB treatment sensitized primary nociceptive afferents and generated an ipsilateral supra-spinal pro-nociceptive mechanism. In addition, sensitization to heat induced by the UVB treatment strengthened an ipsilateral anti-nociceptive process elicited by heat-pain. In...Continue Reading

References

Mar 1, 1997·Muscle & Nerve·J EllrichH C Hopf
Mar 4, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·H KaubeJ Ellrich
Mar 6, 2002·Journal of Neurophysiology·A RomanielloG Cruccu
Jun 28, 2002·Trends in Neurosciences·Frank PorrecaG F Gebhart
May 4, 2004·Annals of Neurology·Anne Louise Oaklander, Jennifer M Brown
Feb 22, 2005·Psychophysiology·Terry D BlumenthalAnton van Boxtel
Feb 7, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Chee Wan Koh, Peter D Drummond
Jun 30, 2006·Psychophysiology·David McIntyreDouglas Carroll
Dec 22, 2006·Journal of Neurophysiology·Dénes BudaiDonald A Simone
Jan 28, 2009·European Journal of Pain : EJP·Lone Knudsen, Peter D Drummond
Apr 28, 2009·Progress in Neurobiology·Ryan K Butler, David P Finn
Jun 29, 2010·Annals of Neurology·Rami BursteinDavid Borsook
Dec 21, 2010·The Journal of Pain : Official Journal of the American Pain Society·Lone Knudsen, Peter D Drummond
Jun 28, 2011·The Journal of Pain : Official Journal of the American Pain Society·Lone KnudsenPeter D Drummond
Nov 20, 2012·Frontiers in Integrative Neuroscience·Peter D Drummond
May 7, 2013·The Journal of Pain : Official Journal of the American Pain Society·Benjamin WeinkaufRoman Rukwied
Nov 13, 2013·European Journal of Pain : EJP·B RukwiedM Schmelz
Jun 3, 2015·European Journal of Pain : EJP·L Vo, P D Drummond
Aug 9, 2016·The Journal of Pain : Official Journal of the American Pain Society·Lechi VoPeter D Drummond

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