Painful stimuli evoke potentials recorded from the medial temporal lobe in humans.

Neuroscience
C C LiuF A Lenz

Abstract

The role of human medial temporal structures in fear conditioning has led to the suggestion that neurons in these structures might respond to painful stimuli. We have now tested the hypothesis that recordings from these structures will demonstrate potentials related to the selective activation of cutaneous nociceptors by a painful laser stimulus (laser evoked potential, LEP) (Kenton B, Coger R, Crue B, Pinsky J, Friedman Y, Carmon A (1980) Neurosci Lett 17:301-306). Recordings were carried out through electrodes implanted bilaterally in these structures for the investigation of intractable epilepsy. Reproducible LEPs were commonly recorded both bilaterally and unilaterally, while LEPs were recorded at contacts on the left (9/14, P=0.257) as commonly as on the right (5/14), independent of the hand stimulated. Along electrodes traversing the amygdala the majority of LEPs were recorded from dorsal contacts near the central nucleus of the amygdala and the nucleus basalis. Stimulus evoked changes in theta activity were observed at contacts on the right at which isolated early negative LEPs (N2*) responses could be recorded. Contacts at which LEPs could be recorded were as commonly located in medial temporal structures with evidence ...Continue Reading

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Citations

Aug 10, 2012·Cerebral Cortex·Irene CristoforiAngela Sirigu
Aug 14, 2013·Molecular Pain·Stéphanie Grégoire, Volker Neugebauer
Mar 20, 2012·The Journal of Pain : Official Journal of the American Pain Society·Catherine A Spuz, George S Borszcz
Jul 4, 2013·Journal of Affective Disorders·Marcele Regine de CarvalhoHagop Souren Akiskal
Oct 8, 2013·Pharmacology, Biochemistry, and Behavior·A Vania ApkarianSoundar Regunathan
Mar 14, 2014·Social Cognitive and Affective Neuroscience·Dongtao WeiJiang Qiu
Dec 6, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Chun Po YenAij Lie Kwan
Aug 2, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Valéry LegrainLéon Plaghki
Jun 15, 2011·Pain·Philippe GoffauxSerge Marchand
Feb 19, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hatice KumruJosep Valls-Sole
Aug 30, 2008·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Luis CarretiéManuel Tapia
Mar 25, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Tali BenromanoRuth Defrin

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