PMID: 8615074Jan 1, 1995Paper

Paired helical filament tau (PHFtau) in Niemann-Pick type C disease is similar to PHFtau in Alzheimer's disease

Acta Neuropathologica
I A AuerJ Q Trojanowski

Abstract

Niemann-Pick Type C disease (NPC) is a cholesterol storage disease with defects in the intracellular trafficking of exogenous cholesterol derived from low density lipoproteins. In NPC cases with a chronic progressive course, neurofibrillary tangles (NFTs) that consist of paired helical filaments (PHFs) have been reported. To determine if NPC tangles contain abnormal tau proteins (known as PHFtau) similar to those found in Alzheimer's disease (AD) tangles, we examined the brains of five NPC cases by immunohistochemical and Western blot methods using a library of antibodies to defined epitopes of PHFtau. We show here that PHFtau in tangle-rich NPC brains is indistinguishable from PHFtau in AD brains. We speculate, that the generation of PHFtau in NPC may induce a cascade of pathological events that contribute to the widespread degeneration of neurons, and that these events may be similar in NPC and AD.

References

Mar 1, 1979·Annals of Neurology·K WisniewskiH M Wisniewski
Nov 1, 1978·Annals of Neurology·D S Horoupian, S S Yang
Feb 15, 1992·American Journal of Medical Genetics·C F RoffP G Pentchev
Jan 1, 1991·Developmental Neuroscience·J C TurpinN Baumann
Aug 11, 1995·The Journal of Biological Chemistry·P SeubertJ Q Trojanowski
Jan 1, 1995·Acta Neuropathologica·K SuzukiE D Carstea
Feb 1, 1995·Brain : a Journal of Neurology·S LoveC P Case
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M GoedertV M Lee

❮ Previous
Next ❯

Citations

Oct 24, 1997·Annals of Neurology·L A ReedJ Q Trojanowski
Apr 12, 2001·The Journal of Comparative Neurology·D C GermanJ M Dietschy
Oct 23, 2002·Journal of Neuroscience Research·Katsuhiko Yanagisawa
May 8, 2010·Journal of Inherited Metabolic Disease·Kim M Hemsley, John J Hopwood
Oct 24, 1998·Trends in Neurosciences·M G Spillantini, M Goedert
Dec 22, 2000·Neurobiology of Aging·J W HussemanI Vincent
Sep 11, 2008·Expert Reviews in Molecular Medicine·Chris D Pacheco, Andrew P Lieberman
Feb 24, 2001·Journal of Neurochemistry·Q W FanM Michikawa
Oct 23, 2002·Journal of Neurochemistry·Ben A Bahr, Jennifer Bendiske
Dec 17, 2008·Human Molecular Genetics·Chris D PachecoAndrew P Lieberman
Dec 17, 2009·Human Molecular Genetics·Matthew J ElrickAndrew P Lieberman
Aug 9, 2012·Human Molecular Genetics·Matthew J ElrickAndrew P Lieberman
May 28, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Sumimasa Yamashita
Feb 15, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M WalterfangD Velakoulis
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·M G SpillantiniB Ghetti
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·X BiG Lynch
Jul 12, 2011·Annual Review of Cell and Developmental Biology·Susan C Su, Li-Huei Tsai
Mar 7, 2014·Human Molecular Genetics·You-hai XuGregory A Grabowski
Mar 31, 2005·Seminars in Cell & Developmental Biology·Jean E VanceBarbara Karten
May 18, 1999·Molecular and Chemical Neuropathology·D A Shackelford, R Y Yeh
Jun 12, 2002·Free Radical Biology & Medicine·Benoit I GiassonJohn Q Trojanowski
Sep 8, 1998·Current Opinion in Structural Biology·Y Lange, T L Steck
Apr 11, 2012·Journal of Neuropathology and Experimental Neurology·Peter T NelsonThomas G Beach
May 20, 2014·Molecular Neurobiology·Jia-Hao SunLan Tan
May 2, 2015·Chemical Research in Toxicology·Cristina AngeloniSilvana Hrelia
Jun 1, 2012·Autophagy·Andrew P LiebermanAndrea Ballabio
Jul 10, 2012·Ageing Research Reviews·Michael A Castello, Salvador Soriano
Oct 1, 2014·ACS Chemical Neuroscience·María Del Carmen Cárdenas-AguayoMarco Antonio Meraz-Ríos
Dec 24, 2004·Biochimica Et Biophysica Acta·Lester I BinderRobert W Berry
Dec 26, 2012·Molecular Genetics and Metabolism·Mark WalterfangDennis Velakoulis
Jul 21, 2009·Brain Research Bulletin·Natasa Bulat, Christian Widmann
Dec 24, 2004·Biochimica Et Biophysica Acta·William H Stoothoff, Gail V W Johnson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.