Paired-pulse depression at photoreceptor synapses

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Katalin RablWallace Thoreson

Abstract

Synaptic depression produced by repetitive stimulation is likely to be particularly important in shaping responses of second-order retinal neurons at the tonically active photoreceptor synapse. We analyzed the time course and mechanisms of synaptic depression at rod and cone synapses using paired-pulse protocols involving two complementary measurements of exocytosis: (1) paired whole-cell recordings of the postsynaptic current (PSC) in second-order retinal neurons and (2) capacitance measurements of vesicular membrane fusion in rods and cones. PSCs in ON bipolar, OFF bipolar, and horizontal cells evoked by stimulation of either rods or cones recovered from paired-pulse depression (PPD) at rates similar to the recovery of exocytotic capacitance changes in rods and cones. Correlation between presynaptic and postsynaptic measures of recovery from PPD suggests that 80-90% of the depression at these synapses is presynaptic in origin. Consistent with a predominantly presynaptic mechanism, inhibiting desensitization of postsynaptic glutamate receptors had little effect on PPD. The depression of exocytotic capacitance changes exceeded depression of the presynaptic calcium current, suggesting that it is primarily caused by a depletion o...Continue Reading

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Citations

Apr 3, 2010·Biological cybernetics·Mikhail Y LipinW Rowland Taylor
Oct 24, 2007·Molecular Neurobiology·Wallace B Thoreson
Dec 21, 2007·Visual Neuroscience·Dwight A BurkhardtMichael A Sikora
Dec 30, 2008·Visual Neuroscience·Sue-Yeon ChoiRichard H Kramer
Nov 26, 2010·Visual Neuroscience·Dwight A Burkhardt
Feb 17, 2009·Nature Neuroscience·Skyler L JackmanRichard H Kramer
Jun 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Qiang LiuErik M Jorgensen
Aug 31, 2012·Journal of Neurophysiology·Mark D KvartaBruce R Johnson
Nov 20, 2009·Journal of Neurophysiology·Theodore M BartolettiWallace B Thoreson
May 18, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Miao TianRichard H Kramer
Dec 15, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew J Van Hook, Wallace B Thoreson
Oct 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Botir T SagdullaevPeter D Lukasiewicz
Nov 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Norbert BabaiWallace B Thoreson
Apr 15, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Soyoun ChoHenrique von Gersdorff
Jun 23, 2007·The Journal of Physiology·Ruth Heidelberger
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Oct 12, 2007·Journal of Neurophysiology·Alyosha Molnar, Frank Werblin
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Oct 6, 2017·Frontiers in Cellular Neuroscience·Xiangyi WenWallace B Thoreson
Mar 30, 2021·Pflügers Archiv : European journal of physiology·Wallace B Thoreson
Nov 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yuchen WangKirill A Martemyanov

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