Paired-related homeodomain proteins Prx1 and Prx2 are expressed in embryonic pituitary stem/progenitor cells and may be involved in the early stage of pituitary differentiation

Journal of Neuroendocrinology
Takao SusaY Kato

Abstract

We recently cloned a paired-related homeodomain protein Prx2 as a novel factor in the pituitary. In the present study, we investigated the ontogenic profiles of Prx2 and another cognate Prx1 in the rat embryonic pituitary. Quantitative real-time polymerase chain reaction showed low expression of Prx2 and a marked increase of Prx1 on rat embryonic day (E)20.5. Immunohistochemical analyses using an antibody that recognises both proteins, with the aim of investigating their roles in pituitary organogenesis, demonstrated that PRXs first appear in the Rathke's pouch on E13.5 in the pituitary stem/progenitor cells expressing Prop1 and Sox2. After E16.5, the number of Prx-expressing cells was increased in both anterior and intermediate lobes. SOX2(+) stem/progenitor cells in the intermediate lobe started to produce PRXs, and PRX(+) /SOX2(+) /PROP1(+) -cells were present on the anterior side of the marginal cell layer and were scattered in the parenchyma of the anterior lobe. On the other hand, PRX(+) -cells negative for PROP1 and SOX2 were located in the anterior lobe. Analysis of the relationship with pituitary endocrine cells revealed that a part of PRX(+) /PROP1(-) /SOX2(-) -cells in the anterior lobe co-expressed all types of horm...Continue Reading

References

Mar 1, 1991·Mechanisms of Development·D J OpsteltenF Meijlink
May 1, 1981·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·S DaikokuK Yoshinaga
Dec 16, 1993·Nature·Y XiongD Beach
Nov 4, 2000·Mammalian Genome : Official Journal of the International Mammalian Genome Society·R A NorrisM J Kern
Dec 19, 2001·The Anatomical Record·Elizabeth S Chesterman, Michael J Kern
Feb 20, 2002·Matrix Biology : Journal of the International Society for Matrix Biology·Lajos MátésIbolya Kiss
Sep 26, 2006·Journal of Dental Research·J M MitchellM J Kern
Mar 6, 2007·Neuroendocrinology·Hugo Vankelecom
May 19, 2007·Seminars in Cell & Developmental Biology·Hugo Vankelecom
Jul 7, 2007·Physiological Reviews·Xiaoyan ZhuMichael G Rosenfeld
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Teddy FauquierIain C A F Robinson
Feb 26, 2008·Experimental Biology and Medicine·Feng Jiang, Branko Stefanovic
May 7, 2008·Journal of Cellular Physiology·Olivier Duverger, Maria I Morasso
Jul 8, 2008·Journal of Neuroendocrinology·S Devnath, K Inoue
May 7, 2009·Stem Cells·Jianghai ChenHugo Vankelecom
May 16, 2009·Biochemical and Biophysical Research Communications·Saishu YoshidaYukio Kato
Jun 25, 2009·The Journal of Reproduction and Development·Takao SusaYukio Kato
Sep 25, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Anamaria BalicMina Mina
Nov 18, 2009·General and Comparative Endocrinology·Hugo Vankelecom, Lies Gremeaux
Dec 23, 2009·Molecular and Cellular Endocrinology·S W DavisS A Camper
Aug 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xianghuai LuMark S Nanes
Dec 15, 2010·The European Journal of Neuroscience·Hugo Vankelecom
Jan 26, 2011·Human Molecular Genetics·Miriam Aza-CarmonaKaren E Heath

❮ Previous
Next ❯

Citations

Sep 13, 2013·Cell and Tissue Research·Hideji YakoYukio Kato
Sep 3, 2013·Molecular and Cellular Endocrinology·Hugo Vankelecom, Jianghai Chen
Apr 29, 2014·Cell and Tissue Research·Masashi HiguchiYukio Kato
Nov 29, 2015·Cell and Tissue Research·Naoko KannoYukio Kato
Jul 16, 2015·Biotechnology Letters·Hae Young KoSoonhag Kim
Jun 3, 2014·The Journal of Reproduction and Development·Hiroki UeharuYukio Kato
May 9, 2014·The Journal of Reproduction and Development·Saishu YoshidaYukio Kato
Feb 9, 2016·The Journal of Reproduction and Development·Ryutaro MoriyamaYukio Kato
Oct 11, 2016·Molecular and Cellular Endocrinology·Gabriela CarrenoJuan Pedro Martinez-Barbera
Sep 1, 2017·The Journal of Endocrinology·Scott HastonJuan Pedro Martinez-Barbera
Jun 16, 2017·The Journal of Endocrinology·Benoit CoxHugo Vankelecom
Mar 15, 2018·Neuroendocrinology·John P RussellCynthia L Andoniadou
Mar 11, 2020·Frontiers in Endocrinology·Roberto WürthTullio Florio
Jun 3, 2014·The Journal of Reproduction and Development·Saishu YoshidaYukio Kato
Nov 23, 2020·Histochemistry and Cell Biology·Kotaro HoriguchiShunji Ohsako

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.