Pairing Speech Sounds With Vagus Nerve Stimulation Drives Stimulus-specific Cortical Plasticity

Brain Stimulation
Crystal T EngineerM P Kilgard

Abstract

Individuals with communication disorders, such as aphasia, exhibit weak auditory cortex responses to speech sounds and language impairments. Previous studies have demonstrated that pairing vagus nerve stimulation (VNS) with tones or tone trains can enhance both the spectral and temporal processing of sounds in auditory cortex, and can be used to reverse pathological primary auditory cortex (A1) plasticity in a rodent model of chronic tinnitus. We predicted that pairing VNS with speech sounds would strengthen the A1 response to the paired speech sounds. The speech sounds 'rad' and 'lad' were paired with VNS three hundred times per day for twenty days. A1 responses to both paired and novel speech sounds were recorded 24 h after the last VNS pairing session in anesthetized rats. Response strength, latency and neurometric decoding were compared between VNS speech paired and control rats. Our results show that VNS paired with speech sounds strengthened the auditory cortex response to the paired sounds, but did not strengthen the amplitude of the response to novel speech sounds. Responses to the paired sounds were faster and less variable in VNS speech paired rats compared to control rats. Neural plasticity that was specific to the f...Continue Reading

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Citations

Jan 30, 2016·Brain Stimulation·Daniel R HulseyMichael P Kilgard
Oct 16, 2015·Brain Stimulation·M S BorlandM P Kilgard
Dec 17, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Seth A Hays
Jun 15, 2016·Proceedings of the National Academy of Sciences of the United States of America·Lauren N WhitehurstSara C Mednick
Jun 20, 2019·Journal of Neurophysiology·Michael S BorlandCrystal T Engineer
Jun 7, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Flavia R Carreno, Alan Frazer
Jul 12, 2017·Journal of Neurodevelopmental Disorders·Crystal T EngineerMichael P Kilgard
Sep 13, 2020·Journal of Personalized Medicine·James Douglas BremnerOmer T Inan
Aug 18, 2020·NPJ Science of Learning·Fernando LlanosBharath Chandrasekaran
Aug 18, 2020·Brain Stimulation·Katherine S AdcockCrystal T Engineer
Apr 15, 2020·Brain Stimulation·Devin AdairMarom Bikson
Dec 22, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rimenez R SouzaMichael P Kilgard
Jul 25, 2018·Brain Stimulation·E P BuellM P Kilgard
Nov 10, 2018·Brain Stimulation·Robert A MorrisonSeth A Hays
Feb 13, 2021·NPJ Science of Learning·Fernando LlanosBharath Chandrasekaran
Jan 31, 2017·Brain Stimulation·Crystal T EngineerMichael P Kilgard
Aug 1, 2018·Neuroscience·Kristofer W LoerwaldMichael P Kilgard
Nov 14, 2017·Neuroscience·Michael S BorlandMichael P Kilgard
Jun 15, 2021·Frontiers in Neuroscience·Natalia Yakunina, Eui-Cheol Nam

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