PAK1 Expression in Pancreatic Cancer: Clinicopathological Characteristics and Prognostic Significance

Clinical Medicine Insights. Oncology
Nikolaos SymeonidisConstantinos Simopoulos

Abstract

Improvement of the management of pancreatic cancer requires a better understanding of the genetic and molecular changes responsible for the development of the disease. The family of p21-activated kinases (PAKs) and especially PAK1 appears to mediate many cellular processes that contribute to the development and progression of pancreatic cancer, but the clinical relevance of PAK1 expression with the disease still remains unclear. Aim of the study was to assess the clinical value and the potential prognostic significance of PAK1 in pancreatic adenocarcinoma. We investigated the relationship between the PAK1 expression and the clinical and histopathologic characteristics of pancreatic cancer patients and the potential significance of PAK1 on survival. We examined tissue samples from 51 patients operated for pancreatic cancer. PAK1 expression was investigated with immunohistochemistry and correlated to clinicopathological parameters. PAK1 was detected in all tumor samples and high expression was found in most patients. High PAK1 expression was also associated with younger age and well-differentiated tumors, but no association was found between PAK1 expression and Tumor-Node-Metastasis stage as well as deceased or alive status on fo...Continue Reading

References

Apr 6, 2002·Circulation Research·William B KiossesMartin Alexander Schwartz
Oct 18, 2002·Journal of Cellular Physiology·Rakesh Kumar, Ratna K Vadlamudi
Oct 25, 2003·Cellular Signalling·Raymond E Menard, Raymond R Mattingly
May 18, 2006·Journal of the National Cancer Institute·Caroline HolmGöran Landberg
May 26, 2006·Nature Reviews. Cancer·Rakesh KumarChristopher J Barnes
Jul 14, 2006·Journal of Molecular Biology·Michelle PirruccelloJohn Kuriyan
Jul 22, 2008·Trends in Biochemical Sciences·Jeyanthy EswaranStefan Knapp
Jan 30, 2009·Cancer Research·Subhash C ChauhanMeena Jaggi
May 26, 2009·Oncogene·P R MolliR Kumar
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Jul 8, 2011·World Journal of Gastroenterology : WJG·Miroslav ZavoralMarek Minarik
Oct 27, 2011·Molecular Cancer Therapeutics·Subhash C ChauhanMeena Jaggi
Dec 14, 2011·Molecular Carcinogenesis·Cristina BosettiPaolo Boffetta
May 5, 2012·Journal of Medicinal Chemistry·Chuangxing GuoBrion W Murray
Jun 2, 2012·EMBO Reports·Yohendran BaskaranEd Manser
Jul 31, 2014·The Journal of Pathology·Wei ZhouKlaus P Hoeflich
Mar 21, 2015·The Journal of Surgical Research·Bao SongZhongfa Xu

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Methods Mentioned

BETA
GTPases
xenografts

Software Mentioned

R
R Foundation for Statistical Computing

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