PALADIN:Protein Alignment for Functional Profiling Whole Metagenome Shotgun Data

BioRxiv : the Preprint Server for Biology
Anthony WestbrookMatthew D MacManes

Abstract

Whole metagenome shotgun sequencing is a powerful approach for assaying the functional potential of microbial communities. Presently, we lack tools that efficiently and accurately align DNA reads against protein references, the technique necessary for constructing a functional profile. Here, we present PALADIN - a novel modification of Burrows-Wheeler Aligner that provides more accurate alignment and orders-of-magnitude improved efficiency by directly mapping in protein space.

Related Concepts

Whole-Genome Shotgun Sequencing
Metagenome
Anatomical Space Structure
PALD1 gene
Microbial
Device, Prosthesis Alignment
Paladin protein, human
Shotgun Sequencing
PALD1
DNA

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