Palindromic rheumatism: a unique and enigmatic entity with a complex relationship with rheumatoid arthritis.

Expert Review of Clinical Immunology
R SanmartiJ D Canete

Abstract

Palindromic rheumatism (PR) is a form of relapsing/remitting arthritis that may evolve to chronic rheumatic disease, mainly rheumatoid arthritis (RA). The exact nature of PR is unclear, as it may be considered a disease in itself, an abortive form of RA or just a pre-RA stage. The authors review the most relevant epidemiological and clinical aspects of PR, especially the pathogenetic role of autoimmunity in PR, with most patients having a characteristic autoantibody profile similar to that observed in RA. The role of autoinflammation is also discussed. A literature review on the rate of RA progression and its prognostic factors was analyzed. Data on the efficacy of drug therapies used to treat PR are presented. PubMed was searched using the terms 'palindromic rheumatism' OR 'palindromic arthritis'. PR is a disease entity with a close but unclear relationship with RA. In PR there is an unmet need, which is to clarify the clinical spectrum and elucidate the risk factors for evolution to RA. The role of autoimmunity and the autoinflammatory component should be investigated. Since most patients evolve to RA, PR may display a unique therapeutic opportunity to avoid this evolution.

References

Oct 1, 1992·The American Journal of Medicine·P A Guerne, M H Weisman
Dec 1, 1989·Clinical Rheumatology·A EliakimS Sukenik
May 16, 1987·British Medical Journal·P HanonenM Oka
Jan 1, 1987·Scandinavian Journal of Rheumatology·P HannonenM Oka
Nov 1, 1986·British Journal of Rheumatology·L R FisherM Shipley
Mar 1, 1985·Annals of the Rheumatic Diseases·P HannonenM Oka
Jul 1, 1966·Annals of the Rheumatic Diseases·S Mattingly
Jul 1, 1971·Annals of the Rheumatic Diseases·M H WilliamsS Mattingly
Dec 1, 1983·Annals of the Rheumatic Diseases·A PinesO Frankl
Sep 30, 2004·Best Practice & Research. Clinical Rheumatology·Raimon SanmartiGeorgina Salvador
Nov 1, 2005·Journal of Autoimmunity·René R P de VriesRené E M Toes
Jun 28, 2006·Arthritis and Rheumatism·Juan D CañeteJordi Yagüe
Oct 14, 2006·Annals of the Rheumatic Diseases·S-K KimJ-B Jun
Sep 1, 2007·Scandinavian Journal of Rheumatology·L-Y LuP-K Sung
Aug 4, 2009·The Journal of Rheumatology·Essi KoskinenTuulikki Sokka
Aug 28, 2009·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Hsin-Hua ChenDer-Yuan Chen
Nov 4, 2010·Revista médica de Chile·Barbara C FinnJulio E Bruetman
Feb 5, 2011·Arthritis Research & Therapy·Heidi KokkonenSolbritt Rantapää-Dahlqvist
Jul 28, 2011·Arthritis and Rheumatism·Lotte A van de StadtDirkjan van Schaardenburg
Oct 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jing ShiLeendert A Trouw
Nov 1, 2011·Annals of the Rheumatic Diseases·Serena BugattiCarlomaurizio Montecucco
Aug 18, 2012·International Journal of Rheumatic Diseases·Alireza KhabbaziSakinehkhatoon Sharif
Oct 3, 2012·The Journal of Rheumatology·Steven J Katz, Anthony S Russell
Sep 6, 2017·PloS One·Feng-Han LinZhiwen Shang
Feb 15, 2018·Pediatric Rheumatology Online Journal·Yonatan Butbul-AvielGil Amarilyo
Oct 10, 2018·Annals of the Rheumatic Diseases·Kulveer MankiaPaul Emery
Dec 24, 2018·Annals of the Rheumatic Diseases·Kulveer MankiaPaul Emery
May 12, 2019·Clinical Rheumatology·Padmaja RaghavanPadmanabha D Shenoy
Aug 3, 2019·The Journal of Rheumatology·Raul Castellanos-MoreiraRaimon Sanmarti
Aug 30, 2019·Arthritis & Rheumatology·Lindsay B KelmensonKevin D Deane
Oct 9, 2019·Nature Reviews. Rheumatology·Kulveer Mankia, Paul Emery
Dec 25, 2019·ACR Open Rheumatology·L EllingwoodUNKNOWN CATCH Investigators

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Sep 16, 2021·International Journal of Clinical Practice·Hadiseh KavandiAlireza Khabbazi

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