Palivizumab for prophylaxis against respiratory syncytial virus infection in children with cystic fibrosis

The Cochrane Database of Systematic Reviews
Karen A RobinsonNaomi McKoy

Abstract

Respiratory syncytial virus infection causes acute lung infection in infants and young children worldwide, resulting in considerable morbidity and mortality. Children with cystic fibrosis are prone to recurrent lung inflammation, bacterial colonisation and subsequent chronic airway disease, putting them at risk for severe respiratory syncytial virus infections requiring intensive care and respiratory support. No treatment currently exists, hence prevention is important. Palivizumab is effective in reducing respiratory syncytial virus hospitalisation rates and is recommended for prophylaxis in high-risk children with other conditions. It is unclear if palivizumab can prevent respiratory syncytial virus hospitalisations and intensive care unit admissions in children with cystic fibrosis. To determine the efficacy and safety of palivizumab (Synagis(®)) compared with placebo, no prophylaxis or other prophylaxis, in preventing hospitalisation and mortality from respiratory syncytial virus infection in children with cystic fibrosis. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register and scanned references of the eligible study and related reviews.Date of last search: 25 October 2011. Randomised and q...Continue Reading

Citations

Jul 21, 2016·The Cochrane Database of Systematic Reviews·Karen A RobinsonIan J Saldanha
Sep 1, 2012·European Journal of Microbiology & Immunology·H FrickmannA E Zautner
May 2, 2013·The Cochrane Database of Systematic Reviews·Tea AndabakaBruno Barsic
Jun 19, 2013·Pediatric Pulmonology·Mirella GaboliManuel Sánchez-Solís de Querol

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